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N6-methyladenosine and Neurological Diseases

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Abstract

N6-methyladenosine (m6A) is a dynamic reversible methylation modification of the adenosine N6 position and is the most common chemical epigenetic modification among mRNA post-transcriptional modifications, including methylation, demethylation, and recognition. Post-transcriptional modification involves multiple protein molecules, including METTL3, METTL14, WTAP, KIAA1429, ALKBH5, YTHDF1/2/3, and YTHDC1/2. m6A-related proteins are expressed in almost all cells. However, the abnormal expression of m6A-related proteins may occur in the nervous system, thereby affecting neuritogenesis, brain volume, learning and memory, memory formation and consolidation, etc., and is implicated in the development of diseases, such as Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, depression, epilepsy, and brain tumors. This review focuses on the functions of m6A in the development of central nervous system diseases, thus contributing to a deeper understanding of disease pathogenesis and providing potential clinical therapeutic targets for neurological diseases.

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Acknowledgements

We would like to express our gratitude to all those helped me during the writing of this manuscript. We apologize to all researchers whose relevant contributions were not cited due to space limitations.

Funding

This work was supported by grants from the National Natural Science Foundation of China (No.81903030); Outstanding Young Aid Program for Education Department of Hunan Province (Grant No.20B511); the Natural Science Foundation of Hunan Province, China (No. 2021JJ40481); University-level research projects of South China University (NO.190XQD019); Graduate Student Scientific Research Innovation Project of University of South China (NO.S202110555298).

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  1. Nan Zhang and Chunhong Ding have contributed equally.

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  1. Department of Physiology, Institute of Neuroscience Research, Hengyang Key Laboratory of Neurodegeneration and Cognitive Impairment, Hengyang Medical College, University of South China, 28 West Changsheng Road, Hengyang, 421001, Hunan, China

    Nan Zhang, Chunhong Ding, Yuxin Zuo, Yu Peng & Lielian Zuo

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Lielian Zuo proposed and revised the manuscript. Nan Zhang and Chunhong Ding co-writed this manuscript and contributed equally to this work. All authors reviewed the manuscript and all approved of the final version.

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Zhang, N., Ding, C., Zuo, Y. et al. N6-methyladenosine and Neurological Diseases. Mol Neurobiol 59, 1925–1937 (2022). https://doi.org/10.1007/s12035-022-02739-0

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