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Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide-based azetidinone derivatives as potent antibacterial and antifungal agents

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Abstract

Twelve compounds belonging to series N-[3-chloro-2-oxo-4-(substituted)phenylazetidin-1-yl]-2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide (5a–l) were synthesized. These compounds were evaluated for their in vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa and antifungal activity against C. albicans, A. niger and A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by their spectral data interpretation. Compound 5g having p-dimethylaminophenyl group on 4-position of azetidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1H-quinoxaline-2-one, was found to be active against all the bacterial and fungal strains under investigation.

A new series of compounds belonging to N-[3-chloro-2-oxo-4-(substituted) phenylazetidin-1-yl]-2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide was synthesized and all the newly synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities.

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Authors and Affiliations

  1. Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering and Technology, Knowledge Park-I, Greater Noida, 201 308, India

    SHIV KUMAR & MD. AKRAM MINHAJ

  2. Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, 250 005, India

    NITIN KUMAR

  3. Maharaja Surajmal Institute of Pharmacy, Janak Puri, New Delhi, 110 058, India

    SUSHMA DRABU

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  1. SHIV KUMAR
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  2. NITIN KUMAR
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  4. MD. AKRAM MINHAJ
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Correspondence to SHIV KUMAR.

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KUMAR, S., KUMAR, N., DRABU, S. et al. Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide-based azetidinone derivatives as potent antibacterial and antifungal agents. J Chem Sci 125, 129–139 (2013). https://doi.org/10.1007/s12039-012-0354-x

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  • DOI: https://doi.org/10.1007/s12039-012-0354-x

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