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Efficacy and Safety of Novel Minimally Invasive Neck Dissection Techniques in Oral/Head and Neck Cancer: A Systematic Review and Meta-Analysis

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Abstract

Despite minimally invasive neck dissection (MIND) being popular technique, there is a paucity of literature emphasizing its safety and efficacy. In this meta-analysis, we compared the efficacy and safety of MIND over CND techniques in treating oral/head and neck cancer. We systematically searched PubMed, MEDLINE, Embase, from database inception to January, 2019 for the relevant studies comparing MIND and CND. Two independent reviewers performed quality check and data were extracted for primary outcomes to assess length of hospital stay, duration of surgery, intraoperative blood loss and retrieved lymph nodes. Drainage volume and duration, length of incision, satisfaction of scar and safety were the secondary outcomes. We analyzed the outcomes using standard mean differences (SMDs) and the relative risk that were pooled using random effect meta-analysis. Out of 144 studies, 17 met the final inclusion criteria. MIND technique has shown better overall efficacy with outcomes compared to CND except with duration of surgery (SMD 1.82, 95% CI 0.47–3.17). Lesser hospital stay, better nodal yield and less intra-operative blood loss was observed with MIND over CND. Duration and volume of wound drainage was comparably less in MIND with smaller length of incision. Postoperative complications were less and tolerable with MIND approach with superior cosmetic outcomes. MIND via endoscopic or robotic approach is safe and efficacious with equitable oncological outcomes in terms of lymph nodes yield compared to CND, but it requires longer surgery duration.

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Authors and Affiliations

  1. Surgical Oncology, Fortis Hospital, 154, 9, Bannerghatta Main Rd, Opposite IIM, Sahyadri Layout, Panduranga Nagar, Bengaluru, Karnataka, 560076, India

    Sandeep P. Nayak, V. Sreekanth Reddy, Bharath Gangadhara & Abhilasha Sadhoo

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  1. Sandeep P. Nayak
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  2. V. Sreekanth Reddy
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  3. Bharath Gangadhara
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  4. Abhilasha Sadhoo
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Contributions

Study design and concept: S.P.N.; data acquisition and interpretation: V.S.R.; manuscript: S.P.N., B.G., A.S.

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Correspondence to V. Sreekanth Reddy.

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The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.

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Nayak, S.P., Sreekanth Reddy, V., Gangadhara, B. et al. Efficacy and Safety of Novel Minimally Invasive Neck Dissection Techniques in Oral/Head and Neck Cancer: A Systematic Review and Meta-Analysis. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 2166–2176 (2022). https://doi.org/10.1007/s12070-020-02066-7

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  • DOI: https://doi.org/10.1007/s12070-020-02066-7

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