Abstract
Background
Over 500 million people are estimated to be infected with chronic viral hepatitis with an increasing burden resulting from the infections. In 2010, the World Health Organization recommended national governments develop effective strategies to reduce the global impact of viral hepatitis. Taiwan, to support the implementation of the world’s first national vaccination program, developed the first of a series of 5-year national strategies in 1982. Our study sought to identify the essential constituents of the strategic response to chronic viral hepatitis in Taiwan, which could then be used by other governments to inform best practice in strategy development.
Methods
Semistructured qualitative interviews were conducted with key participants involved in the national response to viral hepatitis in Taiwan (n = 26) and a review of the literature.
Results
The development of a national strategic response is one of several factors in reducing the burden of viral hepatitis in Taiwan. Other critical factors are effective health services, a prioritization of disease prevention, government funding of science and technology, and sustained advocacy informed by a rigorous evidence base. While there has been significant policy, structural and financial commitment to reduce the burden of related to viral hepatitis, essential challenges remain.
Conclusions
Taiwan’s viral hepatitis policy response focuses on clinical interventions and would be strengthened by a broader involvement of interdisciplinary stakeholders, including people with viral hepatitis, and stronger coordination between the policy and government agencies responsible for their implementation.
Similar content being viewed by others
References
Ioannou GN. Chronic hepatitis B infection: a global disease requiring global strategies. Hepatology 2013;58:839–843
Pawlotsky J-M. Building a liver disease policy in the European Union. J Hepatol 2008;48:889–891
Hatzakis A, Van Damme P, Alcorn K, Gore C, Benazzouz M, Berkane S, et al. The State of Hepatitis B and C in the Mediterranean and Balkan Countries: report from a Summit Conference. J Viral Hepatitis 2013;20:1–20
Ward JW, Lok ASF, Thomas DL, El-Serag HB, Kim WR. Report on a single-topic conference on “chronic viral hepatitis-strategies to improve effectiveness of screening and treatment”. Hepatology 2012;55:307–315
World Health Organization. Prevention and control of viral hepatitis infection: framework for global action. Geneva: World Health Organization; 2012
Beasley RP. Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 1988;61:1942–1956
Stevens CE, Beasley RP, Tsui J, Lee W-C. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med 1975;292:771–774
Beasley RP, Hwang LY, Lin CC, Stevens CE, Wang KY, Sun TS, et al. Hepatitis B immune globulin (HBIG) efficacy in the interruption of perinatal transmission of hepatitis B virus carrier state. Initial report of a randomised double-blind placebo-controlled trial. Lancet 1981;2:388–393
Chen D-S, Hsu H-M, Bennett CL, Pajeau TS, Blumberg B, P-y Chang, et al. A program for eradication of hepatitis B from Taiwan by a 10-year, four-dose vaccination program. Cancer Causes Control 1996;7:305–311
Chang M-H, Chen C-J, Lai M-S, Hsu H-M, Wu T-C, Kong M-S, et al. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N Engl J Med 1997;336:1855–1859
Centers for Disease Control. Centers for Disease Control Annual Report 2012. In Department of Health, editor. Taiwan; 2013
Hsieh C-R, Kuo C-W. Cost of Chronic Hepatitis B Virus Infection in Taiwan. J Clin Gastroenterol 2004;38:S148–S152
Mohamed R, Desmond P, Suh D, Amarapurkar D, Gane E, Guangbi Y, et al. Practical difficulties in the management of hepatitis B in the Asian-Pacific region. J Gastroenterol Hepatol 2004;19:958–969
Wait S, Chen D-S. Towards the eradication of hepatitis B in Taiwan. Kaohsiung J Med Sci 2012;28:1–9
Bureau of National Health Insurance. National Health Insurance in Taiwan, 2011–2012 Handbook. In Department of Health Executive Yuan, editor. Taipei; 2011
Republic of China. Acute Viral hepatitis and Measles added to list of reportable diseases. Epidemiology Bulletin; 1985
Chen D-S. Fighting against viral hepatitis: lessons from Taiwan. Hepatology 2011;54:381–392
Chien Y-C, Jan C-F, Kuo H-S, Chen C-J. Nationwide hepatitis B vaccination program in Taiwan: effectiveness in the 20 Years After it was launched. Epidemiol Rev 2006;28:126–135
Lee L-T, Huang H-Y, Huang K-C, Chen C-Y, Lee W-C. Age-period-cohort analysis of hepatocellular carcinoma mortality in Taiwan, 1976–2005. Ann Epidemiol 2009;19:323–328
Department of Health. Prevention and Treatment Plan for Chronic Viral Hepatitis (First stage plan 2012–2016) (Draft). In Department of Health EY, editor. Taipei, Taiwan: The Republic of China; 2012
National Science Council. Presidential science prize, life sciences, academician Juei-Low Sung. Taiwan: National Science Council; 2001
Hsu H-M, Lu C-F, Lee S-C, Lin S-R, Chen D-S. Seroepidemiologic survey for hepatitis B virus infection in Taiwan: the effect of hepatitis B mass immunization. J Infect Dis 1999;179:367–370
Ni YH, Huang LM, Chang MH, Yen CJ, Lu CY, You SL, et al. Two Decades of Universal Hepatitis B Vaccination in Taiwan: impact and Implication for Future Strategies. Gastroenterology 2007;132:1287–1293
Kao J-H, Chen D-S. Hepatitis B vaccination: to boost or not to boost? The Lancet 2005;366:1337–1338
Adult Preventive Health Services Reform—Further Protecting the Health of Citizens. Taiwan Health in the Globe; 2011;7:4–6
Centers for Disease Control. Centers for Disease Control, Annual Report 2011. In Department of Health, editor. Taiwan: Republic of China; 2012
Yang C-H, Yang S-Y, Shen M-H, Kuo H-S. The changing epidemiology of prevalent diagnosed HIV infections in Taiwan, 1984–2005. Int J Drug Policy 2008;19:317–323
Lin S-H, Chen KC, Lee S-Y, Hsiao C-Y, Lee IH, Yeh TL, et al. The economic cost of heroin dependency and quality of life among heroin users in Taiwan. Psychiatry Res 2013;209:512–517
Acknowledgements
The authors would like to thank Ms. Vicki Ang for her organizational and administrative skills as well as her coordination of the project in Taiwan.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Funding
This project was funded by the Coalition to Eradicate Viral Hepatitis in Asia Pacific (CEVHAP). CEVHAP is a nonprofit organization dedicated to public policy reform to reduce the significant health, social and economic burden of viral hepatitis in the Asia Pacific region.
Conflict of interest
Jack Wallace, Marian Pitts, Stephen Locarnini, Jeanne Ellard, Marina Carman and Ding-Shinn Chen have no financial interest to declare in regards to this manuscript.
Ethical standard
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Ethical support for the project came from the La Trobe University Faculty of Health Sciences (FHEC12/6) with all participants providing informed consent before contributing to the study.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Wallace, J., Pitts, M., Locarnini, S. et al. Essential components in developing public policy to control viral hepatitis: lessons from Taiwan. Hepatol Int 10, 355–362 (2016). https://doi.org/10.1007/s12072-015-9660-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12072-015-9660-y