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Novel antiangiogenic therapies against advanced hepatocellular carcinoma (HCC)

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  • New Trends in Clinical Oncology
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Abstract

Angiogenesis is a cornerstone in the process of hepatocarcinogenesis. In the sorafenib era, other antiangiogenic targeted drugs, such as monoclonal antibodies and a new generation of tyrosine kinase inhibitors, have been shown in phase II trials to be safe and effective in the treatment of advanced hepatocellular carcinoma. Several currently active phase III trials are testing these drugs, both in first- and second-line settings. Strategies to overcome primary and acquired resistance to antiangiogenic therapy are urgently needed. Novel biomarkers may help in improving the efficacy of drugs targeting angiogenesis.

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The authors declare that they have no conflict of interest relating to the publication of this manuscript.

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Authors and Affiliations

  1. Medical Oncology Department, Miguel Servet University Hospital, Zaragoza, Spain

    R. A. Pazo-Cid, A. Antón & J. Martínez Trufero

  2. Radiotherapy Department, Miguel Servet University Hospital, Zaragoza, Spain

    M. Lanzuela

  3. Oncology Department, Hospital Clinica Benidorm, Benidorm, Spain

    G. Esquerdo

  4. Oncology Department, Clinica Universidad de Navarra, Pamplona, Spain

    J. L. Pérez-Gracia

  5. USC Medical School, University of Santiago de Compostela, Santiago, Spain

    G. Amigo

  6. Molecular Laboratory, Miguel Servet University Hospital, Zaragoza, Spain

    A. L. García-Otín

  7. Aragon Institute of Health Sciences, Araid Fund, Zaragoza, Spain

    P. Martín-Duque

  8. Medical Oncology Department, Hospital Universitario Miguel Servet, Paseo Isabel la Catolica, 1-3, 50009, Zaragoza, Spain

    R. A. Pazo-Cid

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  1. R. A. Pazo-Cid
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  2. M. Lanzuela
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  4. J. L. Pérez-Gracia
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  7. J. Martínez Trufero
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  8. A. L. García-Otín
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*Supported by an unrestricted educational grant from MSD Oncology.

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Pazo-Cid, R.A., Lanzuela, M., Esquerdo, G. et al. Novel antiangiogenic therapies against advanced hepatocellular carcinoma (HCC). Clin Transl Oncol 14, 564–574 (2012). https://doi.org/10.1007/s12094-012-0842-y

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