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Incidence and survival time trends for Spanish children and adolescents with leukaemia from 1983 to 2007

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Abstract

Objective

We have analysed incidence and survival trends of children and adolescents with leukaemia registered in Spanish population-based cancer registries during the period 1983–2007.

Methods

Childhood and adolescent leukaemia cases were drawn from the 11 Spanish population-based cancer registries. For survival, registries with data for the period 1991–2005 and follow-up until 31-12-2010 were included. Overall incidence trends were evaluated using joinpoint analysis. Observed survival rates were estimated using Kaplan–Meier, and trends were tested using the log-rank test.

Results

Based on 2606 cases (2274 children and 332 adolescents), the overall age-adjusted incidence rate (ASRw) of leukaemia was 47.9 cases per million child-years in children and 23.8 in adolescents. The ASRw of leukaemia increased with an annual percentage change of 9.6 % (95 % CI: 2.2–17.6) until 1990 followed by a stabilisation of rates. In adolescents, incidence did not increase. Five-year survival increased from 66 % in 1991–1995 to 76 % in 2001–2005. By age, survival was dramatically lower in infants (0) and adolescents (15−19) than in the other age groups and no improvement was observed. In both children and adolescents, differences in 5-year survival rates among major subgroups of leukaemias were significant.

Conclusions

The increasing incidence trends observed in childhood leukaemias during the study period were confined to the beginning of the period. Remarkable improvements in survival have been observed in Spanish children with leukaemias. However, this improvement was not observed in infants and adolescents.

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Acknowledgments

The authors thank G. Gatta, L. Botta and R. Capocaccia of EUROCARE for their help with the standardisation of survival in Spain and all the staffs of the cancer registries participating in the study and Elena Pardo for her support with statistical data.

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    Authors and Affiliations

    1. Epidemiology Unit and Girona Cancer Registry (UERCG), Oncology Coordination Plan (PDO), Department of Health, Autonomous Government of Catalonia, Girona, Spain

      R. Marcos-Gragera

    2. Descriptive Epidemiology, Genetics and Cancer Prevention Group [Girona Biomedical Research Institute] IDIBGI, Catalan Institute of Oncology-Girona (ICO), Girona, Spain

      R. Marcos-Gragera

    3. Nursing Department, University of Girona (UdG), Girona, Spain

      R. Marcos-Gragera

    4. Tarragona Cancer Registry, Foundation Society for Cancer Research and Prevention (FUNCA), Reus, Spain

      J. Galceran

    5. Pere Virgili Health Research Institute, Reus, Spain

      J. Galceran

    6. Rovira i Virgili University (URV), Reus, Spain

      J. Galceran

    7. Zaragoza Cancer Registry, Aragon Government, Saragossa, Spain

      C. Martos

    8. Centre of Public Health Research-FISABIO, Valencia, Spain

      C. Martos

    9. Basque Country Cancer Registry, Basque Government, Vitoria-Gasteiz, Spain

      A. L. de Munain

    10. Community Valenciana Childhood Cancer Registry, Public Health Directorate, Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana, Valencia, Spain

      M. Vicente-Raneda

    11. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain

      C. Navarro & D. Salmerón

    12. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain

      C. Navarro & D. Salmerón

    13. Public Health Directorate, Asturias, Spain

      J. R. Quirós-Garcia

    14. Granada Cancer Registry, Andalusian School of Public Health, Granada, Spain

      M.-J. Sánchez

    15. Navarre Cancer Registry, Navarre Public Health Institute, Pamplona, Spain

      E. Ardanaz

    16. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

      E. Ardanaz

    17. Mallorca Cancer Registry, Epidemiology Department, Directorate-General of Public Health and Participation, Palma de Mallorca, Spain

      M. Ramos

    18. Albacete Cancer Registry, Health and Social Welfare Authority, Albacete, Spain

      A. Mateos

    19. Spanish Childhood Cancer Registry (RETI-SEHOP), Spanish Society of Paediatric Haematology and Oncology, University of Valencia, Valencia, Spain

      S. Felipe & R. Peris-Bonet

    20. Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiología y Salud Pública CIBERESP), Madrid, Spain

      C. Martos, C. Navarro, M.-J. Sánchez, E. Ardanaz & D. Salmerón

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    1. R. Marcos-Gragera
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    Correspondence to R. Marcos-Gragera.

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    Funding

    This work was supported by FIS (PI 061742) and (PI 10/01617); Enriqueta Villavecchia Foundation; Red de Investigación temática en cancer RD12/0036/0056 (Rafael Marcos-Gragera) and RD12/0036/0053 (R Peris-Bonet and Jaume Galceran).

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    R. Marcos-Gragera and J. Galceran contributed equally to this study.

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    Marcos-Gragera, R., Galceran, J., Martos, C. et al. Incidence and survival time trends for Spanish children and adolescents with leukaemia from 1983 to 2007. Clin Transl Oncol 19, 301–316 (2017). https://doi.org/10.1007/s12094-016-1531-z

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