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Preclinical and clinical development of palbociclib and future perspectives

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Abstract

Cyclin-dependent kinases (CDKs) play a key role in cell cycle regulation, which makes them a clear therapeutic target to interfere with cell division and proliferation in cancer patients. Palbociclib, a specific inhibitor of CDK4/6 with outstanding clinical efficacy data and limited toxicity, has been recently approved for the treatment of hormone receptor (HR)-positive human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer, either in combination with an aromatase inhibitor or in combination with fulvestrant in women who have received prior endocrine therapy. This review describes the mechanism of action, preclinical experiences and clinical data of palbociclib, with a special focus on integrating this data with the positioning of palbociclib in the current clinical guidelines for advanced HR-positive/HER2-negative breast cancer. Aspects of the ongoing major studies are also presented, as well as future prospects in the development of palbociclib.

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Acknowledgements

The authors wish to thank Dr. Fernando Sánchez-Barbero from HealthCo S.L. (Madrid, Spain) for his help in the preparation of the manuscript. Pfizer provided comment on the first draft of this manuscript, but thereafter authors made all the decisions about its contents.

Funding

Pfizer provided the financial support of medical writing services.

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Authors and Affiliations

  1. Medical Oncology Department, Provincial Hospital of Castellón, Av. Doctor Clará, 19, 12002, Castellón de la Plana, Spain

    E. Martínez de Dueñas & S. Olmos-Antón

  2. Medical Oncology Department, Valencian Institute of Oncology, Valencia, Spain

    J. Gavila-Gregori

  3. La Fe University Hospital, Valencia, Spain

    A. Santaballa-Bertrán

  4. Clinic University Hospital of Valencia, Valencia, Spain

    A. Lluch-Hernández

  5. Oncology Unit, Pfizer Inc., Madrid, Spain

    E. J. Espinal-Domínguez & M. Rivero-Silva

  6. Medical Oncology Department, Arnau de Vilanova University Hospital, Valencia, Spain

    A. Llombart-Cussac

Authors
  1. E. Martínez de Dueñas
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  2. J. Gavila-Gregori
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  3. S. Olmos-Antón
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  4. A. Santaballa-Bertrán
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  5. A. Lluch-Hernández
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  6. E. J. Espinal-Domínguez
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  7. M. Rivero-Silva
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  8. A. Llombart-Cussac
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Corresponding author

Correspondence to E. Martínez de Dueñas.

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The authors declare that they do not have any conflict of interest that may inappropriately influence this work.

Ethical statement

The study has been performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments. This article does not contain any studies with human participants or animals performed by any of the authors.

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de Dueñas, E.M., Gavila-Gregori, J., Olmos-Antón, S. et al. Preclinical and clinical development of palbociclib and future perspectives. Clin Transl Oncol 20, 1136–1144 (2018). https://doi.org/10.1007/s12094-018-1850-3

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  • DOI: https://doi.org/10.1007/s12094-018-1850-3

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