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Childhood and adolescent lymphoma in Spain: incidence and survival trends over 20 years

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Abstract

Background

Lymphoma is the third most common malignancy in children (0–14 years) and the first in adolescents (15–19 years). This population-based study—the largest ever done in Spain—analyses incidence and survival of lymphomas among Spanish children and adolescents.

Patients and methods

1664 lymphoma cases (1983–2007) for incidence and 1030 for survival (1991–2005) followed until 31/12/2010, were provided by 11 cancer registries. Age-adjusted incidence rates (ASRw) to the world standard population were obtained; incidence trends were modelled using the Joinpoint programme, observed survival (OS) was estimated with Kaplan–Meier and trends tested with a log-rank test. Results are presented according to the International Classification of Childhood Cancer-3.

Results

In Spain, the ASRw0–14 for lymphomas was 17.5 per 1.000.000 child-years and 50.0 the specific rate for adolescents. Overall incidence increased significantly during 1983–1997 with no increases thereafter. Patients over 9 years old showed significant rising trends for all subtypes, except for Burkitt lymphoma (BL) in adolescents. During 2001–2005 (age 0–19 years), 5-year OS was 94 (90–98), 73 (64–83) and 86 (78–94) for Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL) and BL, respectively. No improvement in survival was found. The incidence in Spain was higher than overall European rates, but within the range of that in Southern Europe. Comparing OS in Spain 1991–1995 and 2001–2005 with results for Europe of the Automated Childhood Cancer Information System (ACCIS) (1988–1997) and the European cancer registry-based study on survival and care of cancer patients (EUROCARE) (2000–2007), it was similar for HL and lower for NHL and BL.

Conclusions

Systematic monitoring and analysis of lymphoma paediatric data would provide clinical and epidemiological information to improve the health care of these patients and the outcomes for these malignancies in Spain.

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Acknowledgements

This work was supported by FIS (PI 061742) and (PI 10/01617); Enriqueta Villavecchia Foundation; Red de Investigación Temática en Cáncer RD12/0036/0056 (RMG) and RD12/0036/0053 (RPB and JG); and CIBERESP (predoctoral contract to MS). The authors thank E Pardo and A Muñoz for their contribution to the analysis and the critic review of the manuscript.

The Spanish Childhood Cancer Epidemiology Working Group for this study includes also the following cancer registries and collaborators: Albacete (E. Almar, A. Mateos), Asturias (J. R. Quirós), Basque Country (L. Gil, A. López de Munain), Childhood Cancer Registry of the Comunitat Valenciana (C. Sabater, M. Vicente), Girona (R. Marcos-Gragera, L. Vilardell), Granada (M. Rodríguez-Barranco, D. Y. Chang), Mallorca (P. Franch, M. Ramos), Murcia (C. Navarro, M. D. Chirlaque), Navarra (M. Guevara, R. Burgui), Tarragona (M. Carulla, A. Ameijide), Zaragoza (C. Martos) and the Spanish Registry of Childhood Tumours (RETI-SEHOP) (E. Pardo, A. Muñoz).

Author information

Author notes

  1. R. Marcos-Gragera and M. Solans contributed equally to this work.

Authors and Affiliations

  1. Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona, Spain

    R. Marcos-Gragera & M. Solans

  2. Research Group on Statistics, Econometrics and Health (GRECS), University of Girona, Girona, Spain

    R. Marcos-Gragera & M. Solans

  3. CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain

    M. Solans, M. J. Sánchez, M. D. Chirlaque, E. Ardanaz & D. Salmerón

  4. Tarragona Cancer Registry, Foundation Society for Cancer Research and Prevention (FUNCA), Reus, Spain

    J. Galceran

  5. Pere Virgili Health Research Institute, Reus, Spain

    J. Galceran

  6. Rovira i Virgili University (URV), Reus, Spain

    J. Galceran

  7. Department of Paediatrics, Obstetrics and Gynaecology, University of Valencia, Valencia, Spain

    R. Fernández-Delgado

  8. Non-Hodgkin Lymphoma Working Group, Spanish Society of Paediatric Haematology and Oncology (SEHOP), Madrid, Spain

    R. Fernández-Delgado

  9. University Hospital Virgen de la Macarena, Sevilla, Spain

    A. Fernández-Teijeiro

  10. Hodgkin Lymphoma Working Group, Spanish Society of Paediatric Haematology and Oncology, (SEHOP), Madrid, Spain

    A. Fernández-Teijeiro

  11. Albacete Cancer Registry, Health and Social Welfare Authority, Albacete, Spain

    A. Mateos

  12. Asturias Cancer Registry. Public Health Directorate, Asturias, Spain

    J. R. Quirós-Garcia

  13. Childhood Cancer Registry of the C. Valenciana, Public Health Directorate, Health Department, Government of C.Valenciana, Valencia, Spain

    N. Fuster-Camarena

  14. Basque Country Cancer Registry, Basque Government, Bilbao, Spain

    V. De Castro

  15. Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain

    M. J. Sánchez

  16. Mallorca Cancer Registry, Epidemiology Department, Directorate-General of Public Health and Participation, Palma de Mallorca, Spain

    P. Franch

  17. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain

    M. D. Chirlaque

  18. Navarra Public Health Institute, Pamplona, Spain

    E. Ardanaz

  19. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

    E. Ardanaz

  20. Instituto Aragonés de Ciencias de la Salud, Zaragoza, Spain

    C. Martos

  21. Centre of Public Health Research-FISABIO, Valencia, Spain

    C. Martos

  22. Department of Health and Social Sciences, University of Murcia, Murcia, Spain

    D. Salmerón

  23. IMIB-Arrixaca, Murcia, Spain

    D. Salmerón

  24. Spanish Registry of Childhood Tumours (RETI-SEHOP), University of Valencia, Valencia, Spain

    R. Peris-Bonet

Authors
  1. R. Marcos-Gragera
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  2. M. Solans
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  3. J. Galceran
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  4. R. Fernández-Delgado
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  5. A. Fernández-Teijeiro
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  6. A. Mateos
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  7. J. R. Quirós-Garcia
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  8. N. Fuster-Camarena
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  9. V. De Castro
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  10. M. J. Sánchez
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  11. P. Franch
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  12. M. D. Chirlaque
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  13. E. Ardanaz
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  14. C. Martos
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  15. D. Salmerón
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  16. R. Peris-Bonet
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Consortia

The Spanish Childhood Cancer Epidemiology Working Group

  • E. Almar
  • , A. Mateos
  • , J. R. Quirós
  • , L. Gil
  • , A. López de Munain
  • , C. Sabater
  • , M. Vicente
  • , R. Marcos-Gragera
  • , L. Vilardell
  • , M. Rodríguez-Barranco
  • , D. Y. Chang
  • , P. Franch
  • , M. Ramos
  • , C. Navarro
  • , M. D. Chirlaque
  • , M. Guevara
  • , R. Burgui
  • , M. Carulla
  • , A. Ameijide
  • , C. Martos
  • , E. Pardo
  •  & A. Muñoz

Corresponding author

Correspondence to R. Marcos-Gragera.

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Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.

Additional information

The members of The Spanish Childhood Cancer Epidemiology Working Group are listed in Acknowledgements section.

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Marcos-Gragera, R., Solans, M., Galceran, J. et al. Childhood and adolescent lymphoma in Spain: incidence and survival trends over 20 years. Clin Transl Oncol 20, 1289–1301 (2018). https://doi.org/10.1007/s12094-018-1860-1

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  • DOI: https://doi.org/10.1007/s12094-018-1860-1

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