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Cysteamine-CdTe Quantum Dots Electrochemically Synthesized as Fluorescence Probe for Resveratrol

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Abstract

This work proposes a fluorescent probe based on CdTe quantum dots (QDs) for the determination of resveratrol in wine samples. The synthesis of cysteamine (CA) capped CdTe QD was carried out in a one-pot eco-friendly process, resorting to the electrochemical reduction of metallic tellurium powder in a graphite macroelectrode (cavity cell). The reduced species of tellurium (Te2− and Te22−) migrated to an intermediate compartment of the electrochemical cell and in the presence of a cadmium salt and organic stabilizing agent (CA), forming the colloidal dispersion of CdTe in a single step. Under optimum synthesis conditions, the fluorescence intensity of the prepared nanoparticles varied linearly with the resveratrol concentration in the range from 3.25 to 75 μg L−1 (R2 = 0.9984), with a detection limit of 0.97 μg L−1 and RSD of 3.7% (5.0 μg L−1 resveratrol, n = 10). The method was successfully applied to the resveratrol determination in wines, with recoveries from 97.8 to 112.4%. Student’s t test was applied and no statistically significant difference was observed between the two methods (HPLC and proposed), with a confidence level of 95% (ttabulated = 2.45 and tcalculated = 0.38). The resveratrol determination method, by using CdTe-CA QDs as fluorescence probe, was simple, rapid, inexpensive, and sensitive.

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Acknowledgements

The authors acknowledge LNNano-CNPEM (Campinas, Brazil) for the use of the TEM facility. Research fellowships and scholarship granted by CNPq and CAPES are also gratefully acknowledged. The English version was revised by Sidney Pratt, Canadian, BA, MAT (The Johns Hopkins University), RSAdip (TEFL) (Cambridge University).

Funding

Financial support by CAPES (Projeto PVE 093/2012), FACEPE (APQ-0557-1.06/15), and FACEPE/NUQAAPE (APQ-0346-1.06/14).

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Authors and Affiliations

  1. Departamento de Química Fundamental, Universidade Federal de Pernambuco, Av. Jornalista Aníbal Fernandes, s/n - Cidade Universitária, Recife, PE, 50740-560, Brazil

    Natália S. M. Ramos, Denilson V. Freitas, Gustavo C. S. de Souza, Tailândia M. C. Belmiro, Marcelo Navarro & Ana Paula S. Paim

  2. Departamento de Química, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s/n, CEP 52.171-900 Dois Irmãos, Recife, PE, Brazil

    André F. Lavorante

  3. Brazilian Nanotechnology National Laboratory (LNNano), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, Sao Paulo, 13083-970, Brazil

    Erico Teixeira-Neto

  4. LAQV, REQUIMTE, Departamento de Química Aplicada, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal

    Maria C. B. S. M. Montenegro

Authors
  1. Natália S. M. Ramos
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  8. Maria C. B. S. M. Montenegro
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  9. Ana Paula S. Paim
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Corresponding authors

Correspondence to Maria C. B. S. M. Montenegro or Ana Paula S. Paim.

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Conflict of Interest

Natália S. M. Ramos declares that she has no conflict of interest. Denilson V. Freitas declares that he has no conflict of interest. Gustavo C. S. de Souza declares that he has no conflict of interest. Tailândia M. C. Belmiro declares that she has no conflict of interest. Erico Teixeira-Neto declares that he has no conflict of interest. Marcelo Navarro declares that he has no conflict of interest. André F. Lavorante declares that he has no conflict of interest. Maria Conceição B. S. M. Montenegro declares that she has no conflict of interest. Ana Paula S. Paim declares that she has no conflict of interest.

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Ramos, N.S.M., Freitas, D.V., de Souza, G.C.S. et al. Cysteamine-CdTe Quantum Dots Electrochemically Synthesized as Fluorescence Probe for Resveratrol. Food Anal. Methods 11, 3371–3379 (2018). https://doi.org/10.1007/s12161-018-1305-z

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