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Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process

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Abstract

Streptococcus pneumoniae are natural competent bacteria which requires the presence of a pheromone-like molecule to do the transformation process. This study verified the influence of mesoporous silica (SBA-15 and SBA-16) on the transformation process in S. pneumoniae using a donor DNA obtained from a mutant strain of this microorganism (Sp360∆luxS). The results showed that mesoporous silica SBA-15 and SBA-16 particles doubled the transformation ratio frequency compared with negative control (without nanoparticles) in using SBA-15 (ratio 1.81 ± 0.04) and SBA-16 (ratio 2.18 ± 0.22). We demonstrated the how mesoporous silica nanoparticles were able to increase the pneumococcus transformations, which could possibly lead to the acquisition of virulence factor genes and resistance of antibiotics.

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Acknowledgements

We gratefully acknowledge the Brazilian Nanotechnology National Laboratory (LNNano - CNPEM) for TEM measurements.

Funding

This work was funded by the National Council for Scientific and Technological Development (CNPq), São Paulo Research Foundation (FAPESP), and Coordination for the Improvement of Higher Education Personnel (CAPES). This study was funded by São Paulo Research Foundation (2011/14079-2; 2013/22127-2; 2014/50906-9) and National Council for Scientific and Technological Development (307494/2016-0).

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Authors and Affiliations

Authors

Contributions

M.C.K.A. carried out the molecular genetic studies; M.L. participated in the sequence alignment, performed the statistical analysis, and conceived of the study. M.S. and I.O.M synthesized and characterized the SBA-15 and SBA-16 samples. M.C.K.A., M.L., J.D.O., D.M., T.H.T., M.S., and I.O.M help with manuscript writing and data interpretation.

Corresponding author

Correspondence to Marcelo Lancellotti.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Amstalden, MC.K., Oliveira, J.D., Strauss, M. et al. Analysis of the effects of mesoporous silica particles SBA-15 and SBA-16 in Streptococcus pneumoniae transformation process. Folia Microbiol 64, 127–132 (2019). https://doi.org/10.1007/s12223-018-0631-2

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  • DOI: https://doi.org/10.1007/s12223-018-0631-2

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