Abstract
An endophytic Streptomyces sp. (AC-2) was isolated from the root of Cistanches deserticola Y.C.Ma.. Chemical investigations of the culture broth of AC-2 afforded fifteen compounds including K1115 A (1), tyrosol (2), phenylethylamine derivatives (3, 4), cyclic dipeptides (5–8), nucleosides and their aglycones (9–13), N-acetyltryptamine (14), and pyrrole-2-carboxylic acid (15). Only tyrosol can promote an increase of intracellular cAMP special on GPR12 transfected cells, such as CHO and HEK293, which means it may be a possible ligand for GPR12.
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Lin, ZJ., Lu, XM., Zhu, TJ. et al. GPR12 Selections of the metabolites from an endophytic Streptomyces sp. Asociated with Cistanches deserticola . Arch. Pharm. Res. 31, 1108–1114 (2008). https://doi.org/10.1007/s12272-001-1276-4
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DOI: https://doi.org/10.1007/s12272-001-1276-4