Skip to main content
Log in

A new erythrinan alkaloid from the seed of Erythrina addisoniae

  • Research Articles
  • Drug Discovery and Development
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

Phytochemical study on the EtOAc extract of the seed of Erythrina addisoniae (Leguminosae) resulted in the isolation of a new erythrinan alkaloid, erysovine-N-oxide (1), along with eight known alkaloids, erysosalvinone (2), erysodine (3), 1H-indole-3-propanamide (4), glucoerysodine (5), erysotrine (6), erysovine (7), erythraline (8) and erysopine (9). Their chemical structures were identified on the basis of physicochemical and spectroscopic analyses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Amer, M. E., Shamma, M., and Freyer, A. J., The tetracyclic Erythrina alkaloids. J. Nat. Prod., 54, 329–363 (1991).

    Article  CAS  Google Scholar 

  • Bae, E. Y., Na, M., Njamen, D., Mbafor, J. T., Fomum, Z. T., Cui, L., Choung, D. H., Kim, B. Y., Oh, W. K., and Ahn, J. S., Inhibition of protein tyrosine phosphatase 1B by prenylated isoflavonoids isolated from the stem bark of Erythrina addisoniae. Planta Med., 72, 945–948 (2006).

    Article  PubMed  CAS  Google Scholar 

  • Barron, D. and Ibrahim, R. K., Isoprenylated flavonoids-A survey. Phytochemistry, 43, 921–982 (1996).

    Article  CAS  Google Scholar 

  • Benard, F. J. and Majinda, R. R., Erythrinaline alkaloids from the flowers and pods of Erythrina lysistemon and their DPPH radical scavenging properties. Phytochemistry 65, 1397–1404 (2004).

    Article  Google Scholar 

  • Bugge, J., Klaiber, I., Vogler, B., and Kraus, W., Molluscidal pterocarpanes from Erythrina burana and a new indole alkaloid from Erythrina brucei. Pharm. Pharmacol. Lett. 7, 155–156 (1997).

    CAS  Google Scholar 

  • Chawla, A. S. and Jackson, A. H., Erythrina and related alkaloids. Nat. Prod. Rep., 7, 565–575 (1990).

    Article  PubMed  CAS  Google Scholar 

  • Chawla, A. S., Krishnan, T. R., Jackson, A. H., and Scalabrin, D. A., Alkaloidal constituents of Erythrina variegata Bark. Planta Med. 54, 526–528 (1988).

    Article  PubMed  CAS  Google Scholar 

  • Cornelius, C. W. W. and Runner, R. T. M., Two novel glucodienoid alkaloids from Erythrina latissma seeds. J. Nat. Prod. 63, 871–873 (2000).

    Article  Google Scholar 

  • Decker, M. W., Anderson, D. J., Brioni, J. D., Donnelly-Roberts, D. L., Kang, C. H., O’Neill, A. B., Piattoni-Kaplan, M., Swanson, S., and Sullivan, J. P., Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors. Eur. J. Pharm. 280, 79–89 (1995).

    Article  CAS  Google Scholar 

  • Flausino, O. J., Santos, L. A., Verli, H., Pereira, A. M., Bolzani, V. S., and Nunes-de-Sauza, R. L., Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu. J. Nat. Prod. 70, 48–53 (2007a).

    Article  PubMed  CAS  Google Scholar 

  • Flausino, O. A. J., Pereira, A. M., Bolzani, V. S., and Nunesde-Sauza, R. L., Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety. Biol. Pharm. Bull., 30, 375–378 (2007b).

    Article  PubMed  CAS  Google Scholar 

  • Garin-Aguilar, M. E., Luna, J. E., Soto-Hernandez, M., Valencia del Toro, G., and Vazquez, M. M., Effect of crude extracts of Erythrina americana Mill. on aggressive behavior in rats. J. Ethnopharmacol., 69, 189–196 (2000).

    Article  PubMed  CAS  Google Scholar 

  • Ghosal, S., Dutta, S., and Bhattacharya, S. K., Erythrinachemical and pharmacological evaluation II: alkaloids of Erythrina variegata L. J. Pharm. Sci., 61, 1274–1277 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Ito, K., Studies on the alkaloids of Erythrina plants. Yakugaku Zasshi, 119, 340–356 (1999).

    PubMed  CAS  Google Scholar 

  • Juma, B. F. and Majinda, R. R., Erythrinaline alkaloids from the flowers and pods of Erythrina lysistemon and their DPPH radical scavenging properties. Phytochemistry, 65, 1397–1404 (2004).

    Article  PubMed  CAS  Google Scholar 

  • Na, M., Hoang, D. M., Njamen, D., Mbafor, J. T., Fomum, Z. T., Thuong, P. T., Ahn, J. S., and Oh, W. K., Inhibitory effect of 2-arylbenzofurans from Erythrina addisoniae on protein tyrosine phosphatase-1B. Bioorg. Med. Chem. Lett. 17, 3868–3871 (2007).

    Article  PubMed  CAS  Google Scholar 

  • Oliver-Bever, B., Medicinal plants in tropical West Africa; Cambridge University Press, New York, p. 100 (1986).

    Google Scholar 

  • Soto-Hernandez, M. and Jackson, A. H., Erythrina alkaloids: isolation and characterisation of alkaloids from seven Erythrina species. Planta Med. 60, 175–177 (1994).

    Article  PubMed  CAS  Google Scholar 

  • Talla, E., Njamen, D., Mbafor, J. T., Fomum, Z. T., Kamanyi, A., Mbanya, J. C., Giner, R. M., Recio, M. C., Manez, S., and Rios, J. L., Warangalone, the isoflavonoid anti-inflammatory principle of Erythrina addisoniae stem bark. J. Nat. Prod. 66, 891–893 (2003).

    Article  PubMed  CAS  Google Scholar 

  • Wanjala, C. C., Juma, B. F., Bojase, G., Gashe, B. A., and Majinda, R. R., Erythrinaline alkaloids and antimicrobial flavonoids from Erythrina latissima. Planta Med., 68, 640–642 (2002).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Won Keun Oh.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cui, L., Thuong, P.T., Fomum, Z.T. et al. A new erythrinan alkaloid from the seed of Erythrina addisoniae . Arch. Pharm. Res. 32, 325–328 (2009). https://doi.org/10.1007/s12272-009-1302-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12272-009-1302-2

Key words

Navigation