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Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro

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Abstract

A new terthiophene, 3′-hydroxy-2,2′:5′,2″-terthiophene-3′-O-β-d-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-β-d-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2–6), seven triterpenoids (8–14), two coumestans (15 and 16), and four flavonoids (17–20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1–20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2004398) and by a grant from the Bio-Synergy Research Project (NRF-2014M3A9C4066594) of the Ministry of Science, ICT and Future Planning through the National Research Foundation. We thank Korea Basic Science Institute (KBSI) for running NMR and MS experiments.

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Authors and Affiliations

  1. Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Ha-Yeong Kim, Byeol Ryu, Jae-Seung Lee, Jung-Hye Choi & Dae Sik Jang

  2. College of Pharmacy, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Hye Mi Kim, Jung-Hye Choi & Dae Sik Jang

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  1. Ha-Yeong Kim
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  2. Hye Mi Kim
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Correspondence to Dae Sik Jang.

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Kim, HY., Kim, H.M., Ryu, B. et al. Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro. Arch. Pharm. Res. 38, 1963–1969 (2015). https://doi.org/10.1007/s12272-015-0599-2

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  • DOI: https://doi.org/10.1007/s12272-015-0599-2

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