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General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

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Abstract

Recently, increasing attention has been paid to magneto-conjugated polymer core–shell nanoparticles (NPs) as theranostic platforms. However, the utilization of surfactants and extra oxidizing agents with potential toxicity in synthesis, the lack of general methods for the controlled synthesis of various kinds of magnetic NP (MNP)@conjugated polymer NPs, and the difficulty of obtaining balanced magneto-optical properties have greatly limited the applications of magneto-conjugated polymers in theranostics. We developed an in situ surface polymerization method free of extra surfactants and oxidizing agents to synthesize MNP@polypyrrole (PPy) NPs with balanced, prominent magneto-optical properties. MNP@PPy NPs with an adjustable size, different shapes, and a controlled shell thickness were obtained using this method. The method was extended to synthesize other MNP-conjugated polymer core–shell NPs, such as MNP@polyaniline and MNP@poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS). We discuss the formation mechanism of the proposed method according to our experimental results. Finally, using the optical and magnetic properties of the obtained MNP@PEDOT:PSS NPs, in vivo multimodal imaging-guided hyperthermia was induced in mice, achieving an excellent tumor-ablation therapeutic effect. Our work is beneficial for extending the application of MNP-conjugated polymer core–shell NPs in the biomedical field.

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Acknowledgements

The authors are grateful for the professional technical support for the MRI analysis by Center for Biomedical Imaging Research, Tsinghua University. We thank Tsinghua University Initiative Scientific Research Program (No. 20131089199), National Key Research and Development Program of China (No. 2016YFB0700800), and National Natural Science Foundation of China (Nos. 81172182 and 81671829) for support of funding.

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Authors and Affiliations

  1. State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China

    Hao Yan, Lingyun Zhao, Zhongqun Liu, Wensheng Xie, Cai Qiang, Ranran Zhang, Xiaodan Sun & Feiyu Kang

  2. Key Laboratory of Advanced Materials of Ministry of Education of China, Tsinghua University, Beijing, 100084, China

    Hao Yan, Lingyun Zhao, Zhongqun Liu, Wensheng Xie, Cai Qiang, Zhiyuan Xiong, Ranran Zhang & Xiaodan Sun

  3. Engineering Laboratory for Functionalized Carbon Materials, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China

    Hao Yan, Baohua Li & Feiyu Kang

  4. Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China

    Wenting Shang

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  1. Hao Yan
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  2. Lingyun Zhao
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  3. Wenting Shang
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Correspondence to Xiaodan Sun or Feiyu Kang.

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General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

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Yan, H., Zhao, L., Shang, W. et al. General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics. Nano Res. 10, 704–717 (2017). https://doi.org/10.1007/s12274-016-1330-4

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