Skip to main content
Log in

ADHD and dysthymic disorder: Toward understanding this common comorbidity in children and adolescents

  • Published:
Current Attention Disorders Reports

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and dysthymic disorder (DD) are common childhood psychiatric disorders that have a greater-than-chance association. To date, their relationship has not been systematically examined despite their frequent co-occurrence in children and adolescents referred to clinical health services. This article defines ADHD and DD, reviews their characteristics, and outlines the emerging evidence from phenomenological and cognitive neuroscience studies regarding their association. ADHD and, separately, DD are significant drivers for oppositional defiant disorder symptoms in children and adolescents. ADHD and DD both have elevated levels of neurological subtle signs, spatial working memory deficits, and right frontal-striatal-parietal underactivation compared with healthy control participants. ADHD and DD both also have elevated levels of parental psychopathology, with the comorbid group having significantly higher levels than those with ADHD or DD alone. We explore the clinical implications of these findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, edn 4. Washington, DC: American Psychiatric Association; 1994.

    Google Scholar 

  2. Kovacs M, Akiskal HS, Gatsonis C, et al.: Childhood-onset dysthymic disorder: clinical features and prospective naturalistic outcome. Arch Gen Psychiatry 1994, 51:365–374.

    CAS  PubMed  Google Scholar 

  3. Ferro T, Carlson GA, Grayson P, et al.: Depressive disorders: distinction in children. J Am Acad Child Adolesc Psychiatry 1994, 33:664–670.

    Article  CAS  PubMed  Google Scholar 

  4. Masi G, Favilla L, Mucci M, et al.: Depressive symptoms in children and adolescents with dysthymic disorder. Psychopathology 2001, 34:29–35.

    Article  CAS  PubMed  Google Scholar 

  5. Mitchell J, McCauley E, Burke PM, et al.: Phenomenology of depression in children and adolescents. J Am Acad Child Adolesc Psychiatry 1988, 27:12–20.

    Article  CAS  PubMed  Google Scholar 

  6. Kovacs M, Goldston D: Cognitive and social cognitivedevelopment of depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 1991, 30:388–392.

    Article  CAS  PubMed  Google Scholar 

  7. Kovacs M, Obrosky S, Gatsonis C, et al.: First-episode major depression and dysthymic disorder in childhood: clinical and sociodemographic factors in recovery. J Am Acad Child Adolesc Psychiatry 1997, 36:777–784.

    Article  CAS  PubMed  Google Scholar 

  8. Klein DN, Norden KA, Ferro T, et al.: Thirty-month naturalistic follow-up study of early-onset dysthymic disorder: course, diagnostic stability, and prediction of outcome. J Abnorm Psychol 1998, 107:338–348.

    Article  CAS  PubMed  Google Scholar 

  9. Biederman J, Newcorn J, Sprich S: Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am J Psychiatry 1991, 148:564–577.

    CAS  PubMed  Google Scholar 

  10. Angold A, Costello EJ, Erkanli A: Comorbidity. J Child Psychol Psychiatry 1999, 40:57–87.

    Article  CAS  PubMed  Google Scholar 

  11. Maughan B, Rowe R, Messer J: Conduct disorder and oppositional defiant disorder in a national sample: developmental epidemiology. J Child Psychol Psychiatry 2004, 45:609–621.

    Article  PubMed  Google Scholar 

  12. Vance A, Arduca Y, Sanders M: The associations of oppositional defiant behavior in children with attention deficit hyperactivity disorder, combined type (ADHD-CT). J Affect Disord 2005, 86:329–333.

    Article  PubMed  Google Scholar 

  13. Loeber R, Burke JD, Lahey BB: Oppositional defiant and conduct disorders: a review. J Am Acad Child Adolesc Psychiatry 2000, 39:1468–1484.

    Article  CAS  PubMed  Google Scholar 

  14. Taylor E, Schachar R, Thorley G, et al.: Conduct disorder and hyperactivity: I, Separation of hyperactivity and antisocial conduct in British child psychiatric patients. Br J Psychiatry 1986, 149:760–767.

    Article  CAS  PubMed  Google Scholar 

  15. Taylor E, Everitt B, Schachar R, et al.: Conduct disorder and hyperactivity: II, A cluster analytic approach to the identification of a behavioural syndrome. Br J Psychiatry 1986, 149:768–777.

    Article  CAS  PubMed  Google Scholar 

  16. Taylor E, Sandberg S, Thorley G, et al.: The Epidemiology of Childhood Hyperactivity. Institute of Psychiatry Maudsley Monograph. London: Oxford University Press; 1991.

    Google Scholar 

  17. Piek JP, Pitcher TM, Hay DA: Motor coordination and kinaesthesis in boys with attention deficit hyperactivity disorder. Dev Med Child Neurol 1999, 41:159–165.

    Article  CAS  PubMed  Google Scholar 

  18. Shaffer D, Schonfeld I, O’Connor P: Neurological soft signs: their relationship to psychiatric disorder and intelligence in childhood and adolescence. Arch Gen Psychiatry 1985, 42:342–351.

    CAS  PubMed  Google Scholar 

  19. Pine DS, Shaffer D, Shonfeld IS: Persistent emotional disorders in children with neurological soft signs. J Am Acad Child Adolesc Psychiatry 1993, 32:1229–1236.

    Article  CAS  PubMed  Google Scholar 

  20. Pine DS, Wasserman GA, Fried JE, et al.: Neurological soft signs: one-year stability and relationship to psychiatric symptoms in boys. J Am Acad Child Adolesc Psychiatry 1997, 36:1579–1586.

    CAS  PubMed  Google Scholar 

  21. Vance A, Arduca Y, Sanders M, et al.: ADHD, combined type, dysthymic disorder and anxiety disorders: differential patterns of neurodevelopmental deficits. Psychiatry Res 2006, 143:213–222.

    Article  PubMed  Google Scholar 

  22. Faraone SV, Biederman J: Do ADHD and major depression share familial risk factors? J Nerv Ment Dis 1997, 185:533–541.

    Article  CAS  PubMed  Google Scholar 

  23. Mick E, Biederman J, Santangelo S, et al.: The influence of gender in the familial association between ADHD and major depression. J Nerv Ment Dis 2003, 191:699–705.

    Article  PubMed  Google Scholar 

  24. Biederman J, Faraone SV, Keenan K, et al.: Familial association between attention deficit disorder and anxiety disorders. Am J Psychiatry 1991, 148:251–256.

    CAS  PubMed  Google Scholar 

  25. Biederman J, Faraone SV, Keenan K, et al.: Evidence of familial association between attention deficit hyperactivity disorder and major affective disorders. Arch Gen Psychiatry 1991, 48:633–642.

    CAS  PubMed  Google Scholar 

  26. Befera MS, Barkley RA: Hyperactive and normal girls and boys: mother child interaction, parent psychiatric studies and child psychopathology. J Child Psychol Psychiatry 1985, 26:439–452.

    Article  CAS  PubMed  Google Scholar 

  27. Klein D, Riso L, Donaldson SK, et al.: Family study of early-onset dysthymia: mood and personality disorders in relatives of outpatients with dysthymia and episodic major depression and normal controls. Arch Gen Psychiatry 1995, 52:487–496.

    CAS  PubMed  Google Scholar 

  28. Lizardi H, Klein D: Parental psychopathology and reports of the childhood home environment in adults with early-onset dysthymic disorder. J Nerv Ment Dis 2000, 188:63–70.

    Article  CAS  PubMed  Google Scholar 

  29. Vance A: ADHD, combined type in primary school age children: investigations of its association with oppositional defiant, dysthymic and anxiety disorders. In Attention Deficit Hyperactivity Disorder (ADHD) Research. Edited by Larimer MP. New York: Nova Press; 2005:59–94.

    Google Scholar 

  30. Cataldo MG, Nobile M, Lorusso ML, et al.: Impulsivity in depressed children and adolescents: a comparison between behavioural and neuropsychological data. Psychiatry Res 2005, 136:123–133.

    Article  PubMed  Google Scholar 

  31. Lauer RE, Giordani B, Boivin MJ, et al.: Effects of depression on memory performance and metamemory in children. J Am Acad Child Adolesc Psychiatry 1994, 33:679–685.

    Article  CAS  PubMed  Google Scholar 

  32. Matthews K, Coghill D, Rhodes S: Neuropsychological functioning in depressed adolescent girls. J Affect Disord 2008, 111:113–118.

    Article  PubMed  Google Scholar 

  33. Kempton S, Vance A, Maruff P, et al.: Executive function and attention deficit hyperactivity disorder: stimulant medication and better executive function performance in children. Psychol Med 1999, 29:527–538.

    Article  CAS  PubMed  Google Scholar 

  34. Barnett R, Maruff P, Vance A, et al.: Abnormal executive function in attention deficit hyperactivity disorder: the effect of stimulant medication and age on spatial working memory. Psychol Med 2001, 31:1107–1115.

    Article  CAS  PubMed  Google Scholar 

  35. Smyth MM: Interference with rehearsal in spatial working memory in the absence of eye movements. J Exp Psychol 1996, 49:940–949.

    Article  CAS  Google Scholar 

  36. Awh E, Vogel EK, Oh SH: Interactions between attention and working memory. Neuroscience 2006, 139:201–208].

    Article  CAS  PubMed  Google Scholar 

  37. Awh E, Jonides J: Spatial selective attention and spatial working memory. In The Attentive Brain. Edited by Parasuraman R. Cambridge, MA: MIT Press; 1998:353–380.

    Google Scholar 

  38. Goldman-Rakic PS: Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In Handbook of Physiology, the Nervous System Higher Functions of the Brain, vol V. Edited by Plum F. Bethesda, MD: American Physiological Society; 1987:373–417.

    Google Scholar 

  39. Owen AM, Roberts AC, Hodges JR, et al.: Contrasting mechanisms of attentional set-shifting in patients with frontal lobe damage or Parkinson’s disease. Brain 1993, 116:1159–1175.

    Article  PubMed  Google Scholar 

  40. D’Esposito M, Detre JA, Alsop DC, et al.: The neural basis of the central executive system of working memory. Nature 1995, 378:279–281.

    Article  PubMed  Google Scholar 

  41. Franklin T, Lee A, Hall N, et al.: The association of visuospatial working memory with dysthymic disorder in pre-pubertal children. Psychol Med 2009 Jul 17 (Epub ahead of print).

  42. Vance A, Silk T, Rinehart N, et al.: Right parietal dysfunction in children with attention deficit hyperactivity disorder, combined type: a functional MRI study. Mol Psychiatry 2007, 12:826–832.

    Article  CAS  PubMed  Google Scholar 

  43. Owen AM, Evans AC, Petrides M: Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cereb Cortex 1996, 6:31–38.

    Article  CAS  PubMed  Google Scholar 

  44. Castellanos FX, Sonuga-Barke EJS, Milham MP, et al.: Characterizing cognition in ADHD: beyond executive dysfunction. Trends Cogn Sci 2006, 10:117–123.

    Article  PubMed  Google Scholar 

  45. Vance A: Stimulant medication response in ADHD and comorbid anxiety disorder. In A Handbook of ADHD. Edited by Bellgrove M, Fitzgerald M, Gill M. Chichester, United Kingdom: Wiley; 2007:331–354.

    Google Scholar 

  46. Vance A: ADHD and dysthymic disorder in children and adolescents: recent insights from cognitive neuroscience and functional magnetic resonance imaging. In Attention Deficit Hyperactivity Disorder Research. Edited by Gordon SM, Mitchell AE. New York: Nova Press; 2009:1–35.

    Google Scholar 

  47. Steingard RJ, Renshaw PF, Turgelen-Todd D, et al.: Structural abnormalities in brain magnetic resonance images of depressed children. J Am Acad Child Adolesc Psychiatry 1996, 35:307–311.

    Article  CAS  PubMed  Google Scholar 

  48. Lyoo IK, Kwon JS, Lee SJ, et al.: Decrease in genu corpus callosum in medication naïve early onset dysthymia and depressive personality disorder. Biol Psychiatry 2002, 52:1134–1143.

    Article  PubMed  Google Scholar 

  49. Trimble MR, van Elst LT: The amygdala and psychopathological studies in epilepsy. Ann N Y Acad Sci 2003, 985:461–468.

    Article  PubMed  Google Scholar 

  50. Sarikaya A, Karasin E, Cermik TF, et al.: Evaluation of dysthymic disorder with technetium-99 brain single-photon emission tomography. Eur J Nucl Med 1999, 26:260–264.

    Article  CAS  PubMed  Google Scholar 

  51. Tutus A, Simsek A, Sofuoglu S, et al.: Changes in regional cerebral blood flow demonstrated by single-photon emission computed tomography. Psychiatry Res 1998, 83:169–177.

    Article  CAS  PubMed  Google Scholar 

  52. Kowatch RA, Devous MD Sr, Harvey DC, et al.: A SPECT HMPAO study of regional cerebral flow in depressed adolescents and normal controls. Prog Neuropsychopharmacol Biol Psychiatry 1999, 23:643–656.

    Article  CAS  PubMed  Google Scholar 

  53. Thomas KM, Drevets WC, Dahl RE, et al.: Amygdala response to fearful faces in depressed and anxious children. Arch Gen Psychiatry 2001, 58:1057–1063.

    Article  CAS  PubMed  Google Scholar 

  54. Killgore WD, Yurgelen-Todd DA: Ventromedial prefrontal activity correlates with depressed mood in adolescent children. Neuroreport 2006, 17:167–171.

    Article  PubMed  Google Scholar 

  55. Grimm S, Boesonger P, Beck J, et al.: Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. Neuropsychopharmacology 2009, 34:932–943.

    Article  PubMed  Google Scholar 

  56. Wagner G, Koch K, Schachtzabel C, et al.: Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression. J Psychiatry Neurosci 2008, 33:199–208.

    PubMed  Google Scholar 

  57. Liotti M, Mayberg HS, Brannan SK, et al.: Differential limbic-cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders. Biol Psychiatry 2000, 48:30–42.

    Article  CAS  PubMed  Google Scholar 

  58. Silk T, Vance A, Rinehart N, et al.: Decreased frontalstriatal-parietal activation in attention deficit hyperactivity disorder, combined type (ADHD-CT): an fMRI study. Br J Psychiatry 2005, 187:282–283.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alasdair Vance.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vance, A., Winther, J. ADHD and dysthymic disorder: Toward understanding this common comorbidity in children and adolescents. Curr Atten Disord Rep 1, 145–151 (2009). https://doi.org/10.1007/s12618-009-0020-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12618-009-0020-5

Keywords

Navigation