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Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study

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Abstract

Early hemolysis occurs in the hematoma within 24 h in rat model of intracerebral hemorrhage (ICH). The present study investigated the prevalence of early hemolysis in ICH patients using MRI and the relationship between early hemolysis and perihematomal edema. Thirty ICH patients were prospectively enrolled within 24 h of onset. All patients had cranial CT on admission. Cranial MRI with T2 FLAIR-weighted imaging and T2*-weighted imaging were undertaken at days 1 and 14. The evolution of a non-hypointense lesion on T2*-weighted images and the relationship between the volume of that non-hypointense lesion and perihematomal edema volume were investigated. MRI images of 15 patients were analyzed. The median hematoma volume was 16.3 ml on admission. All patients underwent a baseline MRI within 24 h of ICH onset and showed a non-hypointense lesion within the hematoma on T2*-weighted images. The volume of non-hypointense lesion on T2*-weighted image was 6.0 (8.9) ml at day 1 and 8.6 (17.3) ml at day 14. The absolute perihematomal edema volume was 16.0 (17.9) ml and 24.8 (27.5) ml at days 1 and 14, respectively. There was a linear correlation between non-hypointense T2* lesion and perihematomal edema volume at day 1 and day 14 (p < 0.01). Early hemolysis in the hematoma occurs in humans and contributes to the development of perihematomal edema.

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References

  1. Xi G, Keep RF, Hoff JT. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5:53–63.

    Article  Google Scholar 

  2. Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11:720–31.

    Article  CAS  Google Scholar 

  3. Xi G, Keep RF, Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats. J Neurosurg. 1998;89:991–6.

    Article  CAS  Google Scholar 

  4. Dang G, Yang Y, Wu G, Hua Y, Keep RF, Xi G (2016) Early erythrolysis in the hematoma after experimental intracerebral hemorrhage. Transl Stroke Res.

  5. Bradley WG Jr. MR appearance of hemorrhage in the brain. Radiology. 1993;189:15–26.

    Article  Google Scholar 

  6. Macellari F, Paciaroni M, Agnelli G, Caso V. Neuroimaging in intracerebral hemorrhage. Stroke. 2014;45:903–8.

    Article  Google Scholar 

  7. Linfante I, Llinas RH, Caplan LR, Warach S. MRI features of intracerebral hemorrhage within 2 hours from symptom onset. Stroke. 1999;30:2263–7.

    Article  CAS  Google Scholar 

  8. Cao S, Zheng M, Hua Y, Chen G, Keep RF, Xi G. Hematoma changes during clot resolution after experimental intracerebral hemorrhage. Stroke. 2016;47:1626–31.

    Article  Google Scholar 

  9. Gebel JM Jr, Jauch EC, Brott TG, Khoury J, Sauerbeck L, Salisbury S, et al. Natural history of perihematomal edema in patients with hyperacute spontaneous intracerebral hemorrhage. Stroke. 2002;33:2631–5.

    Article  Google Scholar 

  10. Venkatasubramanian C, Mlynash M, Finley-Caulfield A, Eyngorn I, Kalimuthu R, Snider RW, et al. Natural history of perihematomal edema after intracerebral hemorrhage measured by serial magnetic resonance imaging. Stroke. 2011;42:73–80.

    Article  Google Scholar 

  11. Huang F, Xi G, Keep RF, Hua Y, Nemoianu A, Hoff JT. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products. J Neurosurg. 2002;96:287–93.

    Article  Google Scholar 

Download references

Funding

This study was funded by grants NS-090925, NS-096917, and NS-106746 from the National Institutes of Health (NIH) and grant from UMHS-PUHSC Joint Institute.

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Authors and Affiliations

  1. Department of Neurology, Peking University First Hospital, No.8 Xishiku Street, Xicheng District, Beijing, 100034, China

    Ran Liu & Yining Huang

  2. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA

    Ran Liu, Ya Hua, Richard F. Keep & Guohua Xi

  3. Department of Radiology, Peking University First Hospital, Beijing, China

    Haijiao Li & Jiangxi Xiao

Authors
  1. Ran Liu
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  2. Haijiao Li
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  3. Ya Hua
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  4. Richard F. Keep
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  5. Jiangxi Xiao
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  6. Guohua Xi
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  7. Yining Huang
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Corresponding author

Correspondence to Yining Huang.

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The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Liu, R., Li, H., Hua, Y. et al. Early Hemolysis Within Human Intracerebral Hematomas: an MRI Study. Transl. Stroke Res. 10, 52–56 (2019). https://doi.org/10.1007/s12975-018-0630-2

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  • DOI: https://doi.org/10.1007/s12975-018-0630-2

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