Abstract
We aimed to explore the brain imaging correlates of vocal emotion processing in a group of HIV+ individuals and to compare the vocal emotion processing of HIV+ individuals with a group of healthy adults. We conducted multiple linear regressions to determine the cerebral correlates of a newly designed vocal emotion processing test in a sub-group of HIV+ individuals who completed the cerebral magnetic resonance scan (n = 36). Separately, we test whether the association between our test scores and each cerebral measure persisted regardless of the presence of neurocognitive impairment. We also calculated differences in average test scores between the total HIV+ group (n = 100) and a healthy adult group (n = 46). We found a positive association between the test scores and several brain area volumes: right frontal, temporal and parietal lobes, bilateral thalamus, and left hippocampus. We found a negative association between inflammatory markers in frontal white matter and the test scores. After controlling by neurocognitive impairment, several brain area volumes remained positively associated to the prosody test scores. Moreover, the whole HIV+ sample had significantly poorer test scores than healthy adults, but only in the subset of HIV+ individuals with neurocognitive impairment. For the first time, our results suggest that cerebral dysfunctions in particular brain areas involved in the processing of emotional auditory stimuli may occur in HIV+ individuals. These results highlight the need for broad characterization of the neuropsychological consequence of HIV brain damages.
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Acknowledgments
We thank all the volunteers and healthcare personnel who participated in the study: Blanca Arribas, Isabel Barrientos, Jose Ignacio Bernardino, Juan Miguel Castro, Marta Gálvez, Juan González, Maria Luisa Montes, and Francisco Xavier Zamora. Thanks to Fondo de Investigaciones Sanitarias, Insituto de Salúd Carlos III, which supported this work (grant PI10/00483), Alicia González-Baeza (predoctoral fellowship FI11/00338) and Ignacio Pérez-Valero (Juan Rodes Program 13/00016). We also thank “Red de Investigación en SIDA” (AIDS Research Network) (RIS) RD07/0006/2007 which partially supported IdiPAZ AIDS and infectious diseases investigator group.
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González-Baeza, A., Arribas, J.R., Pérez-Valero, I. et al. Vocal emotion processing deficits in HIV-infected individuals. J. Neurovirol. 23, 304–312 (2017). https://doi.org/10.1007/s13365-016-0501-0
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DOI: https://doi.org/10.1007/s13365-016-0501-0