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Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status

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Abstract

Circulating endothelial cells (CECs) and myeloid angiogenic cells (MACs) have the capacity to stabilize human blood vessels in vivo. Evidence suggests that these cells are depleted in dementia and in persons living with HIV (PWH), who have a higher prevalence of dementia and other cognitive deficits associated with aging. However, the associations of CECs and MACs with MRI-based measures of aging brain health, such as hippocampal gray matter volume, have not been previously demonstrated. The present study examined differences in these associations in 51 postmenopausal women with and without HIV infection. Gray matter volume was quantified using MRI. CECs and MACs were enumerated using fluorescence-activated cell sorting. Analyses examined the association of these cell counts with left and right hippocampal gray matter volume while controlling for age and hypertension status. The main finding was an interaction suggesting that compared to controls, postmenopausal PWH with greater levels of CECs and MACs had significantly greater hippocampus GMV. Further research is necessary to examine potential underlying pathophysiological mechanisms in HIV infection linking morpho-functional circulatory reparative processes with more diminished hippocampal volume in postmenopausal women.

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K01HL139722 awarded to R.C.M. and T32AI007384 supporting J.D.L.

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Authors and Affiliations

  1. Department of Psychology, College of Arts and Sciences, University of Miami, Miami, FL, USA

    Roger McIntosh, Kaitlyn Dillon, Angela Szeto & Barry E. Hurwitz

  2. Behavioral Medicine Research Center, University of Miami, Miami, FL, USA

    Roger McIntosh & Barry E. Hurwitz

  3. Division of Public Health Sciences, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA

    Roger McIntosh

  4. Department of Internal Medicine, Broward Health North, Fort Lauderdale, FL, USA

    Melissa Hidalgo

  5. Department of Psychiatry, University of California San Diego, San Diego, CA, USA

    Judith Lobo

  6. Division of Endocrinology, Diabetes and Metabolism, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA

    Barry E. Hurwitz

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McIntosh, R., Hidalgo, M., Lobo, J. et al. Circulating endothelial and angiogenic cells predict hippocampal volume as a function of HIV status. J. Neurovirol. 29, 65–77 (2023). https://doi.org/10.1007/s13365-022-01101-3

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