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Efficient synthesis of new pyrano[2,3-d]pyrimidine-2,4-dione derivatives via a one-pot four-component reaction

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Abstract

This paper reports an efficient method for the synthesis of pyrano[2,3-d]pyrimidine derivatives via a one-pot four-component reaction between N,N-dimethyl barbituric acid, piperidine, aldehydes and 4-hydroxycoumarin. Mild reaction condition, easy purification and good yields are the main feature of this synthesis.

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Acknowledgements

We gratefully acknowledge financial support from the Research Council of University of Sistan and Baluchestan.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, P. O. Box 98135-674, Zahedan, Iran

    Sharmin Irani, Malek Taher Maghsoodlou & Nourallah Hazeri

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  1. Sharmin Irani
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  2. Malek Taher Maghsoodlou
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  3. Nourallah Hazeri
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Correspondence to Malek Taher Maghsoodlou.

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Irani, S., Maghsoodlou, M.T. & Hazeri, N. Efficient synthesis of new pyrano[2,3-d]pyrimidine-2,4-dione derivatives via a one-pot four-component reaction. J IRAN CHEM SOC 14, 1189–1193 (2017). https://doi.org/10.1007/s13738-017-1069-1

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