Abstract
One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and 6-aminouracil for preparation of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been reported. The method involves domino Knoevenagel condensation/Michael addition, and cyclization cascade. The reaction was performed in glycerol which is commercially available, inexpensive and non-toxic compound. High purity of the products, very high yields and wide scope of substrates are advantages of this protocol.
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We gratefully appreciate the University of Sistan and Baluchestan Research Councils for the financial support of this work.
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Morshedi, A., Shaterian, H.R. Green approach to synthesis of new series of 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives. J IRAN CHEM SOC 16, 493–500 (2019). https://doi.org/10.1007/s13738-018-1528-3
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DOI: https://doi.org/10.1007/s13738-018-1528-3