Abstract
Gene polymorphisms in interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) may affect the predisposition of Alzheimer’s disease (AD), but the results of the so far published studies remain controversial. The authors conducted this meta-analysis to assess relationships between IL-6/IL-8/IL-10 polymorphisms and predisposition of AD by pooling the findings of so far published studies. A comprehensive search of Pubmed, Embase, Web of Science, and CNKI was endorsed by the authors to identify the already published studies. Forty-five studies were found to be eligible for meta-analyses. The pooled meta-analyses results showed that genotypic frequencies of IL-6 − 174 G/C, IL-6 − 572 G/C and IL-10 − 1082 A/G polymorphisms among patients with AD and controls differed significantly. Moreover, genotypic frequencies of IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-8 − 251 A/T polymorphisms among patients with AD and controls in Asians also differed significantly. But no such genotypic frequencies’ differences were observed for IL-10 − 819 C/T and 592 C/A polymorphisms. This meta-analysis suggests that IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-10 − 1082 A/G polymorphisms may affect the predisposition of AD in overall population. Moreover, IL-6 − 174 G/C, IL-6 − 572 G/C, and IL-8 − 251 A/T polymorphisms may affect the predisposition of AD in Asians.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gazzaley A, Small SA (2011) Alzheimer's disease. Network 22:173–185
Winner B, Kohl Z, Gage FH (2011) Neurodegenerative disease and adult neurogenesis. Eur J Neurosci 33:1139–1151
Barnes LL, Bennett DA (2014) Alzheimer's disease in African Americans: risk factors and challenges for the future. Health Aff (Millwood) 33:580–586
Faison WE, Schultz SK, Aerssens J, Alvidrez J, Anand R, Farrer LA, Jarvik L, Manly J, McRae T, Murphy GM Jr, Olin JT, Regier D, Sano M (2007) Mintzer JE (2007) Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future. Int Psychogeriatr 19:539–558
Reitz C, Mayeux R (2014) Genetics of Alzheimer's disease in Caribbean Hispanic and African American populations. Biol Psychiatry 75:534–541
Bertram L, Tanzi RE (2005) The genetic epidemiology of neurodegenerative disease. J Clin Invest 115:1449–1457
Ramanan VK, Saykin AJ (2013) Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders. Am J Neurodegener Dis 2:145–175
Reitz C (2015) Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities. Expert Rev Mol Diagn 15:339–348
Newcombe EA, Camats-Perna J, Silva ML, Valmas N, Huat TJ, Medeiros R (2018) Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation 15:276
Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16:358–372
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer's disease. Neurobiol Aging 21:383–421
Domingues C, da Cruz E, Silva OAB, Henriques AG (2017) Impact of cytokines and chemokines on Alzheimer's disease neuropathological hallmarks. Curr Alzheimer Res 14:870–882
Su F, Bai F, Zhang Z (2016) Inflammatory cytokines and Alzheimer's disease: a review from the perspective of genetic polymorphisms. Neurosci Bull 32:469–480
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264–269
Stang A (2010) Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605
Smith AJ, Humphries SE (2009) Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev 20:43–59
Trenova AG, Slavov GS, Manova MG, Miteva LD, Stanilova SA (2018) A role of cytokine gene polymorphisms in cognitive functioning. Folia Med (Plovdiv) 60:191–199
Cong L, Kong X, Wang J, Du J, Xu Z, Xu Y, Zhao Q (2018) Association between SORL1 polymorphisms and the risk of Alzheimer's disease. J Integr Neurosci 17:185–192
Chouraki V, Seshadri S (2014) Genetics of Alzheimer's disease. Adv Genet 87:245–294
Zhang CC, Zhu JX, Wan Y, Tan L, Wang HF, Yu JT, Tan L (2017) Meta-analysis of the association between variants in MAPT and neurodegenerative diseases. Oncotarget 8:44994–45007
Author information
Authors and Affiliations
Contributions
RY and CH designed this meta-analysis. RY and JD searched literatures. FL and PT analyzed the data. RY and CH wrote the manuscript. All authors approved the final manuscript as submitted.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors, thus ethical approval is not required.
Informed consent
For this type of study, formal consent is not required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Yang, R., Duan, J., Luo, F. et al. IL-6, IL-8 and IL-10 polymorphisms may impact predisposition of Alzheimer’s disease: a meta-analysis. Acta Neurol Belg 121, 1505–1512 (2021). https://doi.org/10.1007/s13760-020-01369-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13760-020-01369-4