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Erschienen in: NeuroTransmitter 6/2023

09.06.2023 | Parkinson-Krankheit | Zertifizierte Fortbildung

Fortgeschrittenes idiopathisches Parkinson-Syndrom

Optimierte Therapie motorischer Spätkomplikationen

verfasst von: Dr. med. Marita Thiel, Prof. Dr. med. Wolfgang H. Jost

Erschienen in: NeuroTransmitter | Ausgabe 6/2023

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Die Behandlung motorischer Spätkomplikationen beim idiopathischen Parkinson-Syndrom ist komplex und führt durch die Optimierung der dopaminergen Therapie nicht immer zum gewünschten Behandlungserfolg. Der rechtzeitige Einsatz intensivierter Therapien ist daher ein entscheidender Schritt, der nicht zu lange hinaus gezögert werden darf. Im klinischen Alltag ist es entscheidend, intensivierte Therapien spätestens am Übergang zum fortgeschrittenen Stadium in Betracht zu ziehen und den Erkrankten mit den für ihnen infrage kommenden Behandlungsoptionen vertraut zu machen.
Literatur
1.
Zurück zum Zitat Balestrino R et al. Parkinson disease. Eur J Neurol. 2020;27:27-42 Balestrino R et al. Parkinson disease. Eur J Neurol. 2020;27:27-42
2.
Zurück zum Zitat Mollenhauer B et al. α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 2011;10:230-40 Mollenhauer B et al. α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study. Lancet Neurol. 2011;10:230-40
3.
Zurück zum Zitat Natera-Villalba E et al. Update in the clinical application of focused ultrasound. Curr Opin Neurol. 2022;35:525-35 Natera-Villalba E et al. Update in the clinical application of focused ultrasound. Curr Opin Neurol. 2022;35:525-35
4.
Zurück zum Zitat LeWitt PA. Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics. Mov Disord. 2015;30:64-72 LeWitt PA. Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics. Mov Disord. 2015;30:64-72
5.
Zurück zum Zitat Hechtner MC et al. Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries. Parkinsonism Relat Disord. 2014;20:969-74 Hechtner MC et al. Quality of life in Parkinson's disease patients with motor fluctuations and dyskinesias in five European countries. Parkinsonism Relat Disord. 2014;20:969-74
6.
Zurück zum Zitat Prasad EM, Hung SY. Current Therapies in Clinical Trials of Parkinson's Disease: a 2021 Update. Pharmaceuticals (Basel). 2021;14:717 Prasad EM, Hung SY. Current Therapies in Clinical Trials of Parkinson's Disease: a 2021 Update. Pharmaceuticals (Basel). 2021;14:717
7.
Zurück zum Zitat Farbman ES et al. A 12-month, dose-level blinded safety and efficacy study of levodopa inhalation powder (CVT-301, Inbrija) in patients with Parkinson's disease. Parkinsonism Relat Disord. 2020;81:144-50 Farbman ES et al. A 12-month, dose-level blinded safety and efficacy study of levodopa inhalation powder (CVT-301, Inbrija) in patients with Parkinson's disease. Parkinsonism Relat Disord. 2020;81:144-50
8.
Zurück zum Zitat Reichmann H et al. Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study. Transl Neurodegener. 2020;9:9 Reichmann H et al. Effectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study. Transl Neurodegener. 2020;9:9
9.
Zurück zum Zitat Ferreira JJ et al. Effect of opicapone on levodopa pharmacokinetics in patients with fluctuating Parkinson's dis. Mov Disord 2022;37:2272-83 Ferreira JJ et al. Effect of opicapone on levodopa pharmacokinetics in patients with fluctuating Parkinson's dis. Mov Disord 2022;37:2272-83
10.
Zurück zum Zitat Ferreira JJ et al. Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open-label extens. Eur J Neurol. 2019;26:953-60 Ferreira JJ et al. Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: a pooled analysis of data from two phase 3 clinical trials and their open-label extens. Eur J Neurol. 2019;26:953-60
11.
Zurück zum Zitat Chaudhuri KR et al. Opicapone versus placebo in the treatment of Parkinson's disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN trial. BMC Neurol. 2022;22:88 Chaudhuri KR et al. Opicapone versus placebo in the treatment of Parkinson's disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN trial. BMC Neurol. 2022;22:88
12.
Zurück zum Zitat Ghosh P et al. A Dual Centre Study of Pain in Parkinson's Disease and Its Relationship with Other Non-Motor Symptoms. J Parkinsons Dis. 2020;10:1817-25 Ghosh P et al. A Dual Centre Study of Pain in Parkinson's Disease and Its Relationship with Other Non-Motor Symptoms. J Parkinsons Dis. 2020;10:1817-25
13.
Zurück zum Zitat Tsuboi Y et al. Effects of safinamide adjunct therapy on pain in patients with Parkinson's disease: Post hoc analysis of a Japanese phase 2/3 study. J Neurol Sci. 2021;429:118070 Tsuboi Y et al. Effects of safinamide adjunct therapy on pain in patients with Parkinson's disease: Post hoc analysis of a Japanese phase 2/3 study. J Neurol Sci. 2021;429:118070
14.
Zurück zum Zitat Cattaneo C et al. Long-term efficacy of safinamide on Parkinson's disease chronic pain. Adv Ther. 2018;35:515-22 Cattaneo C et al. Long-term efficacy of safinamide on Parkinson's disease chronic pain. Adv Ther. 2018;35:515-22
15.
Zurück zum Zitat Cattaneo C et al. Long-term efficacy of safinamide on symptoms severity and quality of life in fluctuating Parkinson's disease patients. J Parkinsons Dis. 2020;10:89-97 Cattaneo C et al. Long-term efficacy of safinamide on symptoms severity and quality of life in fluctuating Parkinson's disease patients. J Parkinsons Dis. 2020;10:89-97
16.
Zurück zum Zitat Pahwa R et al. Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study). Mov Disord. 2015;30:788-95 Pahwa R et al. Amantadine extended release for levodopa-induced dyskinesia in Parkinson's disease (EASED Study). Mov Disord. 2015;30:788-95
17.
Zurück zum Zitat Tanner CM et al. EASE LID 2: A 2-Year Open-Label Trial of Gocovri (Amantadine) Extended Release for Dyskinesia in Parkinson's Disease. J Parkinsons Dis. 2020;10:543-58 Tanner CM et al. EASE LID 2: A 2-Year Open-Label Trial of Gocovri (Amantadine) Extended Release for Dyskinesia in Parkinson's Disease. J Parkinsons Dis. 2020;10:543-58
18.
Zurück zum Zitat Olanow CW et al. Dose optimization of apomorphine sublingual film for treating "OFF" episodes in Parkinson's disease. Parkinsonism Relat Disord. 2021;93:27-30 Olanow CW et al. Dose optimization of apomorphine sublingual film for treating "OFF" episodes in Parkinson's disease. Parkinsonism Relat Disord. 2021;93:27-30
19.
Zurück zum Zitat Pedrosa DJ et al. Characterization of advanced Parkinson's disease in Germany: results of the non-interventional OBSERVE-PD study. Neurol Res Pract. 2022;4:9 Pedrosa DJ et al. Characterization of advanced Parkinson's disease in Germany: results of the non-interventional OBSERVE-PD study. Neurol Res Pract. 2022;4:9
20.
Zurück zum Zitat Weiss D et al.Do we start too late? Insights from the real-world non-interventional BALANCE study on the present use of levodopa/carbidopa intestinal gel in advanced Parkinson's disease in Germany and Switzerland. Parkinsonism Relat Disord. 2022;103: 85-91 Weiss D et al.Do we start too late? Insights from the real-world non-interventional BALANCE study on the present use of levodopa/carbidopa intestinal gel in advanced Parkinson's disease in Germany and Switzerland. Parkinsonism Relat Disord. 2022;103: 85-91
21.
Zurück zum Zitat Aldred J et al. Application of the '5-2-1' screening criteria in advanced Parkinson's disease: interim analysis of DUOGLOBE. Neurodegener Dis Manag. 2020;10:309-23 Aldred J et al. Application of the '5-2-1' screening criteria in advanced Parkinson's disease: interim analysis of DUOGLOBE. Neurodegener Dis Manag. 2020;10:309-23
22.
Zurück zum Zitat Freire-Alvarez E et al. Levodopa-carbidopa intestinal gel reduces dyskinesia in Parkinson's disease in a randomized trial. Mov Disord. 2021;36:2615-23 Freire-Alvarez E et al. Levodopa-carbidopa intestinal gel reduces dyskinesia in Parkinson's disease in a randomized trial. Mov Disord. 2021;36:2615-23
23.
Zurück zum Zitat Antonini A et al. The long-term impact of levodopa/carbidopa intestinal gel on 'off'-time in patients with advanced Parkinson's disease: a systematic review. Adv Ther. 2021;38:2854-90 Antonini A et al. The long-term impact of levodopa/carbidopa intestinal gel on 'off'-time in patients with advanced Parkinson's disease: a systematic review. Adv Ther. 2021;38:2854-90
24.
Zurück zum Zitat Trenkwalder C et al. Increased dose of carbidopa with levodopa and entacapone improves "off" time in a randomized trial. Neurology 2019;92:e1487-96 Trenkwalder C et al. Increased dose of carbidopa with levodopa and entacapone improves "off" time in a randomized trial. Neurology 2019;92:e1487-96
25.
Zurück zum Zitat Senek M et al. Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: a randomized crossover study. Mov Disord. 2017;32:283-6 Senek M et al. Levodopa-entacapone-carbidopa intestinal gel in Parkinson's disease: a randomized crossover study. Mov Disord. 2017;32:283-6
26.
Zurück zum Zitat Öthman M et al. Initial experience of the levodopa-entacapone-carbidopa intestinal gel in clinical practice. J Pers Med. 2021;11:254-63 Öthman M et al. Initial experience of the levodopa-entacapone-carbidopa intestinal gel in clinical practice. J Pers Med. 2021;11:254-63
27.
Zurück zum Zitat Nyholm D, Jost WH. Levodopa-entacapone-carbidopa intestinal gel infusion in advanced Parkinson's disease: real-world experience and practical guidance. Ther Adv Neurol Disord. 2022;15:17562864221108018 Nyholm D, Jost WH. Levodopa-entacapone-carbidopa intestinal gel infusion in advanced Parkinson's disease: real-world experience and practical guidance. Ther Adv Neurol Disord. 2022;15:17562864221108018
28.
Zurück zum Zitat Giladi N et al. ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: a randomized, placebo-controlled phase 2 study. Parkinsonism Relat Disord. 2021;91:139-45 Giladi N et al. ND0612 (levodopa/carbidopa for subcutaneous infusion) in patients with Parkinson's disease and motor response fluctuations: a randomized, placebo-controlled phase 2 study. Parkinsonism Relat Disord. 2021;91:139-45
29.
Zurück zum Zitat Rosa-Grilo M et al. The efficacy of apomorphine - A non-motor perspective. Parkinsonism Relat Disord. 2016; 33 Suppl 1: S28-S35 Rosa-Grilo M et al. The efficacy of apomorphine - A non-motor perspective. Parkinsonism Relat Disord. 2016; 33 Suppl 1: S28-S35
30.
Zurück zum Zitat Katzenschlager R et al. Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2018;17:749-59 Katzenschlager R et al. Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2018;17:749-59
31.
Zurück zum Zitat Katzenschlager R et al. Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2018;17:749-59 Katzenschlager R et al. Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Neurol. 2018;17:749-59
32.
Zurück zum Zitat De Cock VC et al. Safety and efficacy of subcutaneous night-time only apomorphine infusion to treat insomnia in patients with Parkinson's disease (APOMORPHEE): a multicentre, randomised, controlled, double-blind crossover study. Lancet Neurol. 2022;21:428-37 De Cock VC et al. Safety and efficacy of subcutaneous night-time only apomorphine infusion to treat insomnia in patients with Parkinson's disease (APOMORPHEE): a multicentre, randomised, controlled, double-blind crossover study. Lancet Neurol. 2022;21:428-37
33.
Zurück zum Zitat Pessoa RR et al.Apomorphine in the treatment of Parkinson's disease: a review. Arq Neuropsiquiatr. 2018;76:840-48 Pessoa RR et al.Apomorphine in the treatment of Parkinson's disease: a review. Arq Neuropsiquiatr. 2018;76:840-48
34.
Zurück zum Zitat Hacker M et al. Early subthalamic nucleus deep brain stimulation in Parkinson's disease reduces long-term medication costs. Clin Neurol Neurosurg. 2021;210:106976 Hacker M et al. Early subthalamic nucleus deep brain stimulation in Parkinson's disease reduces long-term medication costs. Clin Neurol Neurosurg. 2021;210:106976
35.
Zurück zum Zitat Schuepbach WMM et al. Quality of life predicts outcome of deep brain stimulation in early Parkinson disease. Neurology. 2019;92:e1109-20 Schuepbach WMM et al. Quality of life predicts outcome of deep brain stimulation in early Parkinson disease. Neurology. 2019;92:e1109-20
36.
Zurück zum Zitat Hacker ML et al. Deep brain stimulation in early-stage Parkinson disease: Five-year outcomes. Neurology. 2020;95:e393-e401 Hacker ML et al. Deep brain stimulation in early-stage Parkinson disease: Five-year outcomes. Neurology. 2020;95:e393-e401
37.
Zurück zum Zitat Conway ZJ et al. Low-frequency STN-DBS provides acute gait improvements in Parkinson's disease: a double-blinded randomised cross-over feasibility trial. J Neuroeng Rehabil. 2021;18:125 Conway ZJ et al. Low-frequency STN-DBS provides acute gait improvements in Parkinson's disease: a double-blinded randomised cross-over feasibility trial. J Neuroeng Rehabil. 2021;18:125
38.
Zurück zum Zitat Hacker ML et al. Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease. Neurology. 2018;91:e463-71 Hacker ML et al. Effects of deep brain stimulation on rest tremor progression in early stage Parkinson disease. Neurology. 2018;91:e463-71
39.
Zurück zum Zitat Sasaki F et al. Closed-loop programming using external responses for deep brain stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2021;84:47-51 Sasaki F et al. Closed-loop programming using external responses for deep brain stimulation in Parkinson's disease. Parkinsonism Relat Disord. 2021;84:47-51
40.
Zurück zum Zitat Bouthour W et al. Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond. Nat Rev Neurol. 2019;15:343-52 Bouthour W et al. Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond. Nat Rev Neurol. 2019;15:343-52
41.
Zurück zum Zitat Krauss JK et al. Technology of deep brain stimulation: current status and future directions. Nat Rev Neurol. 2021;17:75-87 Krauss JK et al. Technology of deep brain stimulation: current status and future directions. Nat Rev Neurol. 2021;17:75-87
Metadaten
Titel
Fortgeschrittenes idiopathisches Parkinson-Syndrom
Optimierte Therapie motorischer Spätkomplikationen
verfasst von
Dr. med. Marita Thiel
Prof. Dr. med. Wolfgang H. Jost
Publikationsdatum
09.06.2023
Verlag
Springer Medizin
Erschienen in
NeuroTransmitter / Ausgabe 6/2023
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397
DOI
https://doi.org/10.1007/s15016-023-3133-7

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