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Influence of Single and Multi Dose Treatment of Glipizide on Pharmacokinetics and Pharmacodynamics of Irbesartan in Normal and Hypertensive Rats

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Abstract

Purpose

The present study was carried out to investigate the pharmacokinetic and pharmacodynamic drug interaction of irbesartan with glipizide after single and multi dose treatment in normal and hypertensive rat models to evaluate the safety and effectiveness of the combination.

Methods

The study was conducted on normal and 10% fructose solution induced hypertensive rats. Irbesartan and glipizide were administered orally for 7 days and on 8th day blood samples were collected for 12 h at regular time intervals from irbesartan alone and in combination with glipizide treated groups. The blood samples were analyzed for various pharmacokinetic and pharmacodynamic parameters.

Results

Irbesartan caused marked reduction in blood pressure in hypertensive rats. The combination of irbesartan and glipizide in hypertensive rats produce significant change in blood pressure (pharmacodynamic) and also significance in pharmacokinetic parameters of irbesartan with glipizide in single dose and multiple doses.

Conclusion

The results of present study demonstrated that the synergistic activity of irbesartan with glipizide was observed.

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Acknowledgements

We would like to thank management of Vaagdevi College of Pharmacy, Warangal for providing all facilities. Authors were also thankful to A.I.C.T.E for providing fund for lab under MODROBS scheme (8024/RIFD/MOD-354(PVT)/policy-III/2011-2012).

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Authors and Affiliations

  1. Laboratory of Pharmacokinetics and Toxicokinetics, Department of Pharmacology, Vaagdevi College of Pharmacy, Kakatiya University, Warangal, Telangana, 506001, India

    Adepu Anusha & Puchchakayala Goverdhan

  2. Department of Pharmaceutics, Vaagdevi Institute of Pharmaceutical Sciences, Warangal, Telangana, 506005, India

    Dudhipala Narendar

  3. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, 3455, Houston, TX, 77204, USA

    Boini Krishna Murthy

Authors
  1. Adepu Anusha
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  2. Dudhipala Narendar
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  3. Boini Krishna Murthy
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  4. Puchchakayala Goverdhan
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Corresponding author

Correspondence to Puchchakayala Goverdhan.

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Funding

This study was not funded.

Conflict of Interest

Authors declares there is no conflict of interest.

Ethical approval

Prior the investigation, all the animal experiments were reviewed and approved by the Institutional Animal Ethical Committee (IEAC), Vaagdevi pharmacy college, Warangal, India (1047/ac/07/CPCSEA, Dated 24-04-2007). All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Anusha, A., Narendar, D., Krishna Murthy, B. et al. Influence of Single and Multi Dose Treatment of Glipizide on Pharmacokinetics and Pharmacodynamics of Irbesartan in Normal and Hypertensive Rats. High Blood Press Cardiovasc Prev 24, 179–185 (2017). https://doi.org/10.1007/s40292-017-0195-2

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  • DOI: https://doi.org/10.1007/s40292-017-0195-2

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