Opinion statement
Attention deficit/hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD) are reported to frequently co-occur, particularly in children. However, recent research undermines the viability of such comorbidity. Research further suggests that OCD is associated with deficient cognitive functioning, particularly in the domain of executive function. This may be the underlying reason for the high co-occurrence rates of ADHD reported in OCD samples, compared to the relatively low rates of OCD reported in ADHD samples. Furthermore, a contrasting neurobiological, phenomenological, pharmacological, and psychotherapeutic profile between the two disorders further challenges the viability of a genuine comorbidity. In addition, there is a lack of a solid etiological account for such comorbidity—which may be to a large extent mediated by the presence of tic disorders. The consequences of misdiagnosis of OCD as ADHD in children may be dire because of the putative negative impact of stimulant medications on OCD symptoms. It is recommended that clinicians exercise vigilance when facing a potential dual diagnosis of ADHD and OCD. In order to determine whether OCD is the primary disorder clinicians should inquire about the possibility of a background tic disorder, assess compulsive rituals, impulsivity, risk taking, and the level of distress associated with intrusive thoughts. Once OCD has been determined as the primary condition, inattention and executive dysfunction should be carefully considered as an epiphenomenon of obsessive-compulsive symptoms.
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Wolraich ML. Attention deficit hyperactivity disorder: the most studied and yet most controversial diagnosis. Ment Retard Dev Disabil Res Rev. 1999;5(3):163–8. doi:10.1002/(SICI)1098-2779(1999)5:3<163::AID-MRDD1>3.0.CO;2-T.
Nigg JT. ADHD’s controversies. What causes ADHD?: understanding what goes wrong and why. New York: Guilford Press; 2006. p. 3–29.
American Psychiatric A, American Psychiatric A, Force DSMT. Diagnostic and statistical manual of mental disorders : DSM-5. 2013.
Storebo OJ, Simonsen E. The association between ADHD and antisocial personality disorder (ASPD): a review. J Atten Disord. 2013. doi:10.1177/1087054713512150.
Schatz DB, Rostain AL. ADHD with comorbid anxiety: a review of the current literature. J Atten Disord. 2006;10(2):141–9. doi:10.1177/1087054706286698.
Kim EY, Miklowitz DJ. Childhood mania, attention deficit hyperactivity disorder and conduct disorder: a critical review of diagnostic dilemmas. Bipolar Disord. 2002;4(4):215–25.
Chilakamarri JK, Filkowski MM, Ghaemi SN. Misdiagnosis of bipolar disorder in children and adolescents: a comparison with ADHD and major depressive disorder. Ann Clin Psychiatry. 2011;23(1):25–9.
Biederman J, Klein RG, Pine DS, Klein DF. Resolved: mania is mistaken for ADHD in prepubertal children. J Am Acad Child Adolesc Psychiatry. 1998;37(10):1091–6. discussion 6–9.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Arlington: American Psychiatric Association; 2013.
McGough JJ, Barkley RA. Diagnostic controversies in adult attention deficit hyperactivity disorder. Am J Psychiatry. 2004;161(11):1948–56.
Cumyn L, French L, Hechtman L. Comorbidity in adults with attention-deficit hyperactivity disorder. Can J Psychiatry. 2009;54(10):673–83.
McGough JJ, Smalley SL, McCracken JT, Yang M, Del’Homme M, Lynn DE, et al. Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families. Am J Psychiatry. 2005;162(9):1621–7. doi:10.1176/appi.ajp.162.9.1621.
Perry R. Misdiagnosed ADD/ADHD; rediagnosed PDD. J Am Acad Child Psychiatry. 1998;37(1):113–4. doi:10.1097/00004583-199801000-00024.
Mayes SD, Calhoun SL, Mayes RD, Molitoris S. Autism and ADHD: overlapping and discriminating symptoms. Res Autism Spectr Disord. 2012;6(1):277–85. http://dx.doi.org/10.1016/j.rasd.2011.05.009.
Hartley SL, Sikora DM. Which DSM-IV-TR criteria best differentiate high-functioning autism spectrum disorder from ADHD and anxiety disorders in older children? Autism. 2009;13(5):485–509. doi:10.1177/1362361309335717.
Aronen ET, Paavonen EJ, Fjallberg M, Soininen M, Torronen J. Sleep and psychiatric symptoms in school-age children. J Am Acad Child Psychiatry. 2000;39(4):502–8. doi:10.1097/00004583-200004000-00020.
Hartnett DN, Nelson JM, Rinn AN. Gifted or ADHD? The possibilities of misdiagnosis. Roeper Rev. 2004;26(2):73–6. doi:10.1080/02783190409554245.
Abramovitch A, Dar R, Hermesh H, Schweiger A. Comparative neuropsychology of adult obsessive-compulsive disorder and attention deficit/hyperactivity disorder: implications for a novel executive overload model of OCD. J Neuropsychol. 2012;6(2):161–91. doi:10.1111/j.1748-6653.2011.02021.x. This article provides empirical support for the executive overload model of OCD, suggesting that inattention and executive function deficits may stem from OCD symptoms.
Koizumi HM. Obsessive-compulsive symptoms following stimulants. Biol Psychiatry. 1985;20(12):1332–3.
Kouris S. Methylphenidate-induced obsessive-compulsiveness. J Am Acad Child Adolesc Psychiatry. 1998;37(2):135.
Abramovitch A, Dar R, Mittelman A, Schweiger A. Don’t judge a book by its cover: ADHD-like symptoms in obsessive-compulsive disorder. J Obsessive Compuls Relat Disord. 2013;2:53–61.
Coles ME, Schofield CA, Pietrefesa AS. Behavioral inhibition and obsessive-compulsive disorder. J Anxiety Disord. 2006;20(8):1118–32.
Steketee G, Frost RO. Measurement of risk-taking in obsessive-compulsive disorder. Behav Cogn Psychother. 1994;22(04):287–98.
Ettelt S, Grabe HJ, Ruhrmann S, Buhtz F, Hochrein A, Kraft S, et al. Harm avoidance in subjects with obsessive-compulsive disorder and their families. J Affect Disord. 2008;107(1):265–9. doi:10.1016/j.jad.2007.08.017.
Hollander E. Obsessive-compulsive disorder and spectrum across the life span. Int J Psychiatry Clin Pract. 2005;9(2):79–86.
Abramovitch A, Dar R, Mittelman A, Wilhelm S. Comorbidity between attention deficit/hyperactivity disorder and obsessive-compulsive disorder across the lifespan: a systematic and critical review. Harv Rev Psychiatry. 2015;23(4):245–62. doi:10.1097/HRP.0000000000000050. This article provides a comprehensive and critical review examining comorbidity between OCD and ADHD.
Bush G, Valera EM, Seidman LJ. Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biol Psychiatry. 2005;57(11):1273–84.
Harrison BJ, Soriano-Mas C, Pujol J, Ortiz H, Lopez-Sola M, Hernandez-Ribas R, et al. Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch Gen Psychiatry. 2009;66(11):1189–200.
Whiteside SP, Port JD, Abramowitz JS. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res Neuroimaging. 2004;132(1):69–79.
Rubia K, Cubillo A, Woolley J, Brammer MJ, Smith A. Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocation. Hum Brain Mapp. 2011;32(4):601–11. In this unique imaging study, the authors examined brain activity during cognitive tasks between an OCD and ADHD samples.
Norman LJ, Carlisi C, Lukito S, Hart H, Mataix-Cols D, Radua J, et al. Structural and functional brain abnormalities in attention-deficit/hyperactivity disorder and obsessive-compulsive disorder: a comparative meta-analysis. JAMA Psychiatry. 2016. doi:10.1001/jamapsychiatry.2016.0700. This paper reports a recent comparative meta-analysis of structural and functional brain imaging studies in OCD and in ADHD, concluding that there are substantial neurobiological contrasting differences between OCD and ADHD, in both pediatric and adult samples.
Gibbins C, Weiss M. Clinical recommendations in current practice guidelines for diagnosis and treatment of ADHD in adults. Curr Psychiatry Rep. 2007;9(5):420–6.
Bandelow B, Zohar J, Hollander E, Kasper S, Moller HJ, Zohar J, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders—first revision. World J Biol Psychiatry. 2008;9(4):248–312. doi:10.1080/15622970802465807.
Isomura K, Nordsletten AE, Rück C, Ljung R, Ivarsson T, Larsson H et al. Pharmacoepidemiology of obsessive-compulsive disorder: a Swedish nationwide cohort study. Eur Neuropsychopharmacol. in-press. http://dx.doi.org/10.1016/j.euroneuro.2016.02.004.
Delorme R, Gousse V, Roy I, Trandafir A, Mathieu F, Mouren-Simeoni MC, et al. Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder. Eur Psychiatry. 2007;22(1):32–8. doi:10.1016/j.eurpsy.2006.05.002.
Heyman I, Fombonne E, Simmons H, Ford T, Meltzer H, Goodman R. Prevalence of obsessive-compulsive disorder in the British nationwide survey of child mental health. Br J Psychiatry. 2001;179:324–9.
Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–23.
Zohar AH, Ratzoni G, Pauls DL, Apter A, Bleich A, Kron S, et al. An epidemiological study of obsessive-compulsive disorder and related disorders in Israeli adolescents. J Am Acad Child Adolesc Psychiatry. 1992;31(6):1057–61.
Geller DA, Wieland N, Carey K, Vivas F, Petty CR, Johnson J, et al. Perinatal factors affecting expression of obsessive compulsive disorder in children and adolescents. J Child Adolesc Psychopharmacol. 2008;18(4):373–9. doi:10.1089/cap.2007.0112.
Lack CW, Storch EA, Keeley ML, Geffken GR, Ricketts ED, Murphy TK, et al. Quality of life in children and adolescents with obsessive-compulsive disorder: base rates, parent-child agreement, and clinical correlates. Soc Psychiatry Psychiatr Epidemiol. 2009;44(11):935–42. doi:10.1007/s00127-009-0013-9.
Storch EA, Lewin AB, Geffken GR, Morgan JR, Murphy TK. The role of comorbid disruptive behavior in the clinical expression of pediatric obsessive-compulsive disorder. Behav Res Ther. 2010;48(12):1204–10. doi:10.1016/j.brat.2010.09.004.
McConaughy SH, Achenbach TM. Comorbidity of empirically based syndromes in matched general population and clinical samples. J Child Psychol Psychiatry. 1994;35(6):1141–57.
Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164(6):942–8.
Abramovitch A, Mittelman A, Henin A, Geller DA. Neuroimaging and neuropsychological findings in pediatric obsessive-compulsive disorder: a review and developmental considerations. Neuropsychiatry. 2012;2(4):313–29.
Fitzgerald KD, Welsh RC, Stern ER, Angstadt M, Hanna GL, Abelson JL, et al. Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2011;50(9):938–48 e3. doi:10.1016/j.jaac.2011.06.011. In this large imaging study, the authors found that the youngest OCD age group demonstrated frontostriatal connectivity that was different from all other age groups, and one that may resemble connectivity in ADHD.
Abramovitch A, Abramowitz JS, Mittelman A, Stark A, Ramsey K, Geller DA. Research review: neuropsychological test performance in pediatric obsessive–compulsive disorder—a meta-analysis. J Child Psychol Psychiatry. 2015;56(8):837–47. doi:10.1111/jcpp.12414.
Stewart SE, Geller DA, Jenike M, Pauls D, Shaw D, Mullin B, et al. Long-term outcome of pediatric obsessive–compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand. 2004;110(1):4–13. doi:10.1111/j.1600-0447.2004.00302.x.
Geller DA, Biederman J, Faraone SV, Frazier J, Coffey BJ, Kim G, et al. Clinical correlates of obsessive compulsive disorder in children and adolescents referred to specialized and non-specialized clinical settings. Depress Anxiety. 2000;11(4):163–8. These two studies were the first to examine co-occurrence of OCD and ADHD in families.
Geller DA, Biederman J, Griffin S, Jones J, Lefkowitz TR. Comorbidity of juvenile obsessive-compulsive disorder with disruptive behavior disorders. J Am Acad Child Adolesc Psychiatry. 1996;35(12):1637–46. These two studies were the first to examine co-occurrence of OCD and ADHD in families.
Ghanizadeh A. Comorbidity of enuresis in children with attention-deficit/hyperactivity disorder. J Atten Disord. 2010;13(5):464–7. doi:10.1177/1087054709332411.
Zohar AH. The epidemiology of obsessive-compulsive disorder in children and adolescents. Child Adolesc Psychiatr Clin N Am. 1999;8(3):445–60.
Grados MA, Mathews CA. Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications. Biol Psychiatry. 2008;64(3):219–25. doi:10.1016/j.biopsych.2008.01.019.
Kendler KS, Heath A, Martin NG, Eaves LJ. Symptoms of anxiety and depression in a volunteer twin population: the etiologic role of genetic and environmental factors. Arch Gen Psychiatry. 1986;43(3):213–21. doi:10.1001/archpsyc.1986.01800030023002.
Beck AT, Clark DA. Anxiety and depression: an information processing perspective. Anxiety Research. 1988;1(1):23–36. doi:10.1080/10615808808248218.
Nadder TS, Rutter M, Silberg JL, Maes HH, Eaves LJ. Genetic effects on the variation and covariation of attention deficit-hyperactivity disorder (ADHD) and oppositional-defiant disorder/conduct disorder (Odd/CD) symptomatologies across informant and occasion of measurement. Psychol Med. 2002;32(1):39–53.
Pauls DL, Abramovitch A, Rauch SL, Geller DA. Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci. 2014;15(6):410–24. doi:10.1038/nrn3746.
Franke B, Faraone SV, Asherson P, Buitelaar J, Bau CH, Ramos-Quiroga JA, et al. The genetics of attention deficit/hyperactivity disorder in adults, a review. Mol Psychiatry. 2012;17(10):960–87. doi:10.1038/mp.2011.138.
Geller DA, Petty C, Vivas F, Johnson J, Pauls D, Biederman J. Examining the relationship between obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in children and adolescents: a familial risk analysis. BiolPsychiatry. 2007;61(3):316–21.
Geller DA, Petty C, Vivas F, Johnson J, Pauls D, Biederman J. Further evidence for co-segregation between pediatric obsessive compulsive disorder and attention deficit hyperactivity disorder: a familial risk analysis. Biol Psychiatry. 2007;61(12):1388–94.
Abramovitch A, Schweiger A. Unwanted intrusive and worrisome thoughts in adults with attention deficit\hyperactivity disorder. Psychiatry Res. 2009;168(3):230–3.
Brown FC, Katz LJ, Roth RM, Beers SR. The relationship of self-reported subclinical obsessive-compulsive symptoms and impulsivity among adults with AD/HD. Psychiatry Res. 2014;216(1):131–6. http://dx.doi.org/10.1016/j.psychres.2014.01.034.
Frost RO, Steketee G. Perfectionism in obsessive-compulsive disorder patients. Behav Res Ther. 1997;35(4):291–6. http://dx.doi.org/10.1016/S0005-7967(96)00108-8.
Boyer P, Lienard P. Why ritualized behavior? Precaution systems and action parsing in developmental, pathological and cultural rituals. Behav Brain Sci. 2006;29(6):595–613. discussion -50.
Willcutt EG. The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics. 2012;9(3):490–9. doi:10.1007/s13311-012-0135-8.
Alonso P, Menchon JM, Jimenez S, Segalas J, Mataix-Cols D, Jaurrieta N, et al. Personality dimensions in obsessive-compulsive disorder: relation to clinical variables. Psychiatry Res. 2008;157(1-3):159–68.
Bejerot S, Schlette P, Ekselius L, Adolfsson R, von Knorring L. Personality disorders and relationship to personality dimensions measured by the Temperament and Character Inventory in patients with obsessive-compulsive disorder. Acta Psychiatr Scand. 1998;98(3):243–9. doi:10.1111/j.1600-0447.1998.tb10075.x.
Fullana MA, Mataix-Cols D, Caseras X, Alonso P, Manuel MJ, Vallejo J, et al. High sensitivity to punishment and low impulsivity in obsessive-compulsive patients with hoarding symptoms. Psychiatry Res. 2004;129(1):21–7.
Shoval G, Zalsman G, Sher L, Apter A, Weizman A. Clinical characteristics of inpatient adolescents with severe obsessive-compulsive disorder. Depress Anxiety. 2006;23(2):62–70.
Tavares H, Gentil V. Pathological gambling and obsessive-compulsive disorder: towards a spectrum of disorders of volition. Rev Bras Psiquiatr. 2007;29(2):107–17.
Wu KD, Clark LA, Watson D. Relations between Obsessive-Compulsive Disorder and personality: beyond Axis I-Axis II comorbidity. J Anxiety Disord. 2006;20(6):695–717.
Rachman S. A psychological approach to the study of comorbidity. Clin Psychol Rev. 1991;11(4):461–4. doi:10.1016/0272-7358(91)90118-e.
Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry. 2007;164(7):1.
Subcommittee on Attention-Deficit/Hyperactivity Disorder, Steering Committee on Quality Improvement and Management. ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics. 2011;128(5):1007–22.
Serby M. Methylphenidate-induced obsessive-compulsive symptoms in an elderly man. CNS Spectrums. 2003;8(8):612–3.
Woolley JB, Heyman I. Dexamphetamine for obsessive-compulsive disorder. Am J Psychiatry. 2003;160(1):183-.
Lipszyc J, Schachar R. Inhibitory control and psychopathology: a meta-analysis of studies using the stop signal task. J Int Neuropsychol Soc. 2010;16(6):1064–76. doi:10.1017/s1355617710000895.
Snyder HR. Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychol Bull. 2013;139(1):81–132. doi:10.1037/a0028727.
Wright L, Lipszyc J, Dupuis A, Thayapararajah SW, Schachar R. Response inhibition and psychopathology: a meta-analysis of go/no-go task performance. J Abnorm Psychol. 2014:No pagination specified. doi:10.1037/a0036295.
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Abramovitch, A. Misdiagnosis of ADHD in Individuals Diagnosed With Obsessive-Compulsive Disorder: Guidelines for Practitioners. Curr Treat Options Psych 3, 225–234 (2016). https://doi.org/10.1007/s40501-016-0084-7
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DOI: https://doi.org/10.1007/s40501-016-0084-7