Abstract
Background
Acupuncture is widely used as an alternative modality for weight loss. Despite its increasing use, few acupuncture studies have evaluated the effect of a weight loss program on the mental health of obese/overweight participants and none have looked at the effect on those with eating, weight and shape concerns.
Objectives
To investigate the feasibility of conducting an acupuncture study involving overweight or obese individuals undertaking a weight loss program with particular reference to those with eating concerns.
Methods
Thirty-five overweight/obese males and females participated in a single-blinded randomised cross-over study. The two intervention phases were: (1) nutritional counselling plus Traditional Chinese Medicine (TCM) acupuncture and (2) nutritional counselling plus sham acupuncture.
Outcome measures
This study evaluates the feasibility and practicalities of the study including recruitment, retention, adverse events, effectiveness for defining eating and weight concerns, study design and statistics for power calculations.
Conclusion
The outcome measures, the recruitment of those with eating and weight concerns and the acceptability of the intervention demonstrate a larger trial investigating the use of acupuncture for weight loss in those who have elevated eating and weight concerns is feasible.
Similar content being viewed by others
References
Cabroglu M, Ergene N (2007) Electroacupuncture treatment of obesity with psychological symptoms. Int J Neurosci 117:579–590
Abraham S, Llewellyn-Jones D (2001) Eating disorders: the facts, 5th edn. Oxford University Press, Oxford
Grilo CM (2006) Eating and weight disorders. Psychology Press, London
Australian Institute of Health and Welfare (2013) Risk factors to health. http://www.aihw.gov.au/risk-factors/. Accessed 9 Jan 2015
Briggs M (2006) Overweight and obesity in Australia. http://www.aph.gov.au/About_Parliament/Parliamentary_Departments/Parliamentary_Library/Publications_Archive/archive/obesity. Accessed 9 Jan 2015
Belivani M, Dimitroula C, Kasiki N, Apostolopoulou M, Cummiings M, Hatzitolios A (2013) Acupuncture in the treatment of obesity: a narrative review of the literature. Acupunct Med 31(1):88–97. doi:10.1136/acupmed-2012-010247
Sui Y, Zhao HL, Wong VC, Brown N, Li XL, Kwan AKL et al (2012) A systematic review on use of Chinese medicine and acupuncture for the treatment of obesity. Obes Rev 13(May):409–430. doi:10.1111/j.1467-789X.2011.00979
Cho S-H, Lee J-S, Thabane L, Lee J (2009) Acupuncture for obesity; a systematic review and meta analysis. Int J Obes (Lond) 33:183–196. doi:10.1038/ijo.2008.269
Rerksuppaphol L, Rerksuppaphol S (2011) Efficacy of transcutaneous electrical acu-point stimulation compared to electroacupucnture at the main acupoints for weight reduction in obese Thai women. Int J Collab Res Intern Med Public Health 3(11):811–820
Darbandi S, Darbandi M, Mokarram P, Qwji A, Zhao B, Ghayor-Mobarhan M et al (2013) Effects of body electroacupuncture on plasma leptin concentrations in obese and overweight people in Iran: a randomized controlled trial. Altern Ther Health Med. 19(2):24–31
Wang Q, Li W-H, Zhou Q-H, Tang X-D, Zhang X-X, Shu S (2012) Weight reduction effects of acupuncture for obese women with or without perimenopausal syndrome: a pilot observational study. Am J Chin Med 40(6):1157–1166. doi:10.1142/S0192415X12500851
Elder CR, Gullion CM, DeBar LL, Funk KL, Lindberg NM, Ritenbaugh C et al (2012) Randomized trial of tapas acupressure technique for weight loss maintenance. BMC Complement Altern Med 12:19. doi:10.1186/1472-6882-12-19
Mazzoni R, Mannucci E, Rizzello SM, Ricca V, Rotella CM (1999) Failure of acupuncture in the treatment of obesity: a pilot study. Eat Weight Disord 4:198–202
Bosmans G, Goossens L, Braet C (2009) Attachment and weight and shape concerns in inpatient overweight youngsters. Appetite 53:454–456. doi:10.1016/j.appet.2009.08.011
Celio CI, Luce KH, Bryson SW, Winzelberg AJ, Cunning D, Rockwell R et al (2006) Use of diet pills and other dieting aids in a college population with high weight and shape concerns. Int J Eat Disord 39:492–497
Mond JM, Hay PJ, Rodgers B, Owen C (2006) Recurrent binge eating with and without the ‘‘undue influence of weight or shape on self-evaluation’’: implications for the diagnosis of binge eating disorder. Behav Res Ther 45:929–938
Ramacciotti CE, Coli E, Bondi E, Burgalassi A, Massimetti G, Dell’Osso L (2008) Shared psychopathology in obese subjects with and without binge-eating disorder. Int J Eat Disord 41:643–649. doi:10.1002/eat.20544
Roehrig M, Masheb RM, White MA, Grilo CM (2009) Dieting frequency in obese patients with binge eating disorder: behavioral and metabolic correlates. Obesity (Silver Spring) 17:689–697. doi:10.1038/oby.2008.600
Werrija MQ, Jansena A, Mulkensa S, Elgersmab HJ, Amenta AJHA, Hospersa HJ (2009) Adding cognitive therapy to dietetic treatment is associated with less relapse in obesity. J Psychosom Res 67:315–324. doi:10.1016/j.jpsychores.2008.12.011
Burrows A, Cooper M (2002) Possible risk factors in the development of eating disorders in overweight pre-adolescent girls. Int J Obes Relat Metab Disord 26:1268–1273
Chugh R, Puri S (2001) Affluent adolescent girls of Delhi: eating and weight concerns. Br J Nutr 86:535–542
Polivy J, Herman P (2002) Causes of eating disorders. Annu Rev Psychol 53:187–213
Stice E (2001) A prospective test of the dual pathway model of bulimic pathology: mediating effects of dieting and negative effect. J Abnorm Psychol 110:1–12
Garner DM (2004) EDI-3 eating disorder inventory-3-professional manual. PAR Psychological Assessment Resources Inc, Florida
Senn S (2002) Cross-over trials in clinical research. Wiley, West Sussex
A.D.A.M. (2015) Appetite Decreased. http://www.healthcentral.com/ency/408/003121.html. Accessed 9 Jan 2015
National Health and Medical Council. Dietary Guidelines for all Australians. Australian Government; 2003 (cited 13 July 2010). Reference No: N29–N34 Further information: nhmrc.publications@nhmrc.gov.au]. Available from: http://www.nhmrc.gov.au/publications/synopses/dietsyn.htm
Deng T (2000) Practical diagnosis in traditional Chinese medicine. Churchill Livingstone, Edinburgh
Cabroglu M, Ergene N (2005) Electroacupunctre therapy for weight loss reduces serum total cholesterol, triglycerides, and LDL cholesterol levels in obese women. Am J Chin Med 33(4):525–533
Cabroglu M, Ergene N (2006) Changes in levels of serum insulin, C-peptide and glucose after electroacupuncture and diet therapy in obese women. Am J Chin Med 34(3):367–376
Shafshak T (1995) Electroacupuncture and exercise in body weight reduction and their application in rehabilitating patients with knee osteoarthritis. Am J Chin Med 23(1):15–25
Hsu C, Hwang K, Chao C, Lin J, Kao S, Chou P (2005) Effects of electroacupunctre in reducing weight and waist circumference in obese women: a randomized crossover trial. Int J Obes (Lond) 29:1379–1384
Myeong L, Jeong K, Hyun-Ja L, Byung-Chenul S (2006) Effects of abdominal electroacuncture on parameters related to obesity in obese women: A pilot study. Complement Ther Clin Pract 12:97–100
Hsu C, Hwang K, Chao C, Chang H, Chou P (2005) Electroacupuncture in obese women: a randomized, controlled pilot study. J Womens Health (Larchmt) 14(5):434–440
Deadman P, Al-Khafaji M, Baker K (1998) A Manual of Acupuncture. Journal of Chinese Medicine Publications, East Sussex
O'Connor J, Bensky D (1981) Acupuncture: A Comprehensive Text. Shanghai college of traditional medicine. Eastland Press, Chicago
Kraft N (2003) Anorexia nervosa. Orient Med J 11(1):19–23
Beck A, Brown G, Steer R (1996) Manual for the beck depression inventory-II. San Antonio. Psychological Corporation, TX
Spielberger C (1983) State-Trait anxiety inventory for adults, sampler set. Manual, test booklet and scoring key. Consulting Psychologists Press, Inc, Mind Garden
QualityMetric. SF-36v2 Health Survey. 2010 (cited 13 May 2010). Available from: http://www.qualitymetric.com/WhatWeDo/GenericHealthSurveys/SF36v2HealthSurvey/tabid/185/Default.aspx
Quantitative Micro Software (2007) E-Views Statistical Software. Version 6.1
Jones B, Kenward MG (1989) Design and analysis of cross-over trials. Chapman and Hall Ltd, London
G*Power: Statistical Power Analyses for Windows and Mac. 2014 (cited 5 Dec 2014]; 3.1.9.2: Available from: http://www.gpower.hhu.de/en.html
Greenway FL, Fujioka K, Plodkowski RA, Mudaliar S, Guttadauria M, Erickson J et al (2010) Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 376(9741):595–605. doi:10.1016/S0140-6736(10)60888-4
Pi-Sunyer F, Aronne L, Heshmati H, Devin J, Rosenstock J (2006) Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 295(7):761–775
Cabroglu M, Ergene N, Tan U (2006) The treatment of obesity by acupuncture. Int J Neurosci 116:165–175
Yeo S, Kim KS, Lim S (2014) Randomised clinical trial of five ear acupuncture points for the treatment of overweight people. Acupunct Med 32(2):132–138. doi:10.1136/acupmed-2013-010435
Lacey J, Tershakovec A, Foster G (2003) Acupuncture for the treatment of obesity: a review of the evidence. Int J Obes Relat Metab Disord 27:419–427
Acknowledgments
Thanks to Tony at Helio Supply Co for supplying the acupuncture needles. AJM is supported by the Australian Government’s Collaborative Research Networks (CRN) program.
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Appendix 1: Understanding the analysis of a cross-over trial
Appendix 1: Understanding the analysis of a cross-over trial
Cross-over studies have a couple of issues that need to be addressed in the analysis. They are carry-over [“Carry-over is the persistence (whether physically or in terms of effect) of a treatment applied in one period in a subsequent period of treatment” [25].] and a period effect (“Period effect is where a trend affecting the experiment as a whole” [25]) which looks at the effect of the order with which the participant received the treatment.
The approach detailed in “Study design” of Jones and Kenward was followed [42] to address these issues. This approach consists of first performing a t test for the presence of a carry-over effect in those who received acupuncture in the first phase of the trial. The presence of carry-over is tested using a two sample t test for equality of means of \( Y_{1} + Y_{0} \) between those that received acupuncture first and second (page 24, [42]). This approach caters for random effects.
If significant carry-over effects are found, then following the approach of Jones and Kenward (page 28, [42]) the effect of the treatment is measured using a two sample t test on period 0 (both groups first phase only) results only. This tests for equality of means of those who received acupuncture first and those who received sham first.
If no significant carry-over is found, then, another t test is performed for period effect. The presence of a period effect is tested using a two sample t test for equality of means (crossover difference) of \( Y_{1} - Y_{0} \) for those that received acupuncture first and \( Y_{0} - Y_{1} \) for those that received acupuncture second (page 27 [42]).
If significant period effects are found, then following the approach of Jones and Kenward (page 25, [42]), the effect of the treatment is measured using a two sample t test for the equality of the two means: \( Y_{1} - Y_{0} \) for those that received acupuncture first and \( Y_{1} - Y_{0} \) for those that received acupuncture second.
If no significant period effect is found then following the approach of Senn (page 42, [25]) the effectiveness of the acupuncture can be measured using a paired t test. \( \left( {\begin{array}{*{20}c} {Y_{1} - Y_{0} } \\ {Y_{0} - Y_{1} } \\ \end{array} } \right) \), where \( Y_{1} - Y_{0} \) is for acupuncture second and \( Y_{0} - Y_{1} \) for acupuncture first. This pools the groups together and a t test is done for zero means.
Rights and permissions
About this article
Cite this article
Fogarty, S., Stojanovska, L., Harris, D. et al. A randomised cross-over pilot study investigating the use of acupuncture to promote weight loss and mental health in overweight and obese individuals participating in a weight loss program. Eat Weight Disord 20, 379–387 (2015). https://doi.org/10.1007/s40519-014-0175-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40519-014-0175-7