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Childhood trauma determines different clinical and biological manifestations in patients with eating disorders

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Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Purpose

There is a significant relationship between childhood trauma and the development of an eating disorder in adolescence or adulthood, possibly influenced by circulating levels of inflammatory parameters. The main objective is to identify and describe a subgroup of patients with eating disorders and a history of trauma in childhood or adolescence with differential clinical features.

Methods

An observational study on a sample of 55 patients who met the diagnostic criteria for any DSM-5 eating disorder was carried out. Inflammatory parameters in white blood cells were examined. Patients underwent different assessments, including clinical and personality scales.

Results

Patients with a history of trauma had higher scores in the delirious and narcissistic items of the Millon Clinical Multiaxial Inventory (MCMI-II) (p < 0.05) and a higher score in the paranoid item of the SCID-5 Personality Disorders Version (SCID-5-PD) (p < 0.05). Patients with distinguishing personality features were grouped according to the Childhood Trauma Questionnaire sexual subscale. Tumor necrosis alpha (TNF-α) showed a significant association with childhood trauma history.

Conclusions

There is a profile of patients with eating disorders who have increased activity in the inflammatory pathways that, if identified precociously, can benefit from specifically aimed interventions.

Level of evidence

Level V, observational study.

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Acknowledgements

The authors want to particularly acknowledge the patients enrolled in this study for their participation.

Funding

This study was funded through an Intramural Grant awarded to Dra. Díaz-Marsa, from the Network for Biomedical Research in Mental Health (CIBERSAM) and a grant from the Carlos III Institute (FIS-11-0725 and FIS 10-0123). AR has held a Río Hortega Grant, Instituto de Salud Carlos III, Spanish Ministry of Economy and Competiveness. The funders had no role in the study design, data collection, data analysis, data interpretation, or writing of the manuscript.

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Authors and Affiliations

  1. Department of Psychiatry, Hospital Universitario Infanta Leonor, Gran Vía del Este 80, 28030, Madrid, Spain

    Alberto Rodríguez-Quiroga

  2. Department of Psychiatry and Psychology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain

    Alberto Rodríguez-Quiroga, José Luis Carrasco & Marina Díaz-Marsá

  3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain

    Karina S. MacDowell, Juan C. Leza, José Luis Carrasco & Marina Díaz-Marsá

  4. Department of Pharmacology, Medical School, Complutense University, Av. Séneca, 2, 28040, Madrid, Spain

    Karina S. MacDowell & Juan C. Leza

  5. Department of Psychiatry, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos, Calle del Prof Martín Lagos, s/n, 28040, Madrid, Spain

    José Luis Carrasco & Marina Díaz-Marsá

  6. Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Av. Cordoba, s/n, 28041, Madrid, Spain

    Karina S. MacDowell & Juan C. Leza

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  1. Alberto Rodríguez-Quiroga
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  5. Marina Díaz-Marsá
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Contributions

MDM and JLC designed the current study. MDM and ARQ contributed to the acquisition of the data. ARQ and MDM prepared the manuscript. KM and JCL performed biochemical determinations in plasma and cells. JLC checked and edited the article. MDM supervised all aspects of the study.

Corresponding author

Correspondence to Alberto Rodríguez-Quiroga.

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Conflict of interest

ARQ has been a consultant and/or has received fees from Janssen, Lundbeck, and Otsuka. He has previously held a “Río Hortega” grant from Instituto de Salud Carlos III (Spanish Ministry of Economy and Competitiveness).KM has no conflicts of interest. JCL has received grant support from Instituto de Salud Carlos III (Spanish Ministry of Economy, Industry, and Competitiveness), CIBERSAM, Fundación Alicia Koplowitz, and Fundación Mutua Madrileña. JLC and MDM have been a consultant to or have received honoraria or grants from AstraZeneca, Bristol-Myers Squibb, CIBERSAM, Janssen Cilag, Lundbeck, Otsuka, Pfizer, and Roche.

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All procedures performed in studies involving human participants were under the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Rodríguez-Quiroga, A., MacDowell, K.S., Leza, J.C. et al. Childhood trauma determines different clinical and biological manifestations in patients with eating disorders. Eat Weight Disord 26, 847–857 (2021). https://doi.org/10.1007/s40519-020-00922-7

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