Abstract
An acid-mediated three-component reaction for the synthesis of multisubstituted pyrroles has been developed from benzoin, C–H-activated compounds, and ammonium acetate/p-methoxy aniline. The advantage of this one-step metal-free approach is the use of lactic acid as a biodegradable, environmentally benign, and available catalyst and green solvent along with simple purification process involving no chromatographic process, high efficiency, short reaction time, and high yield of products.
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We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.
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Sanchooli Tazeh, K., Hazeri, N., Fatahpour, M. et al. Lactic Acid as a Highly Efficient and Simplified Biocatalyst System for One-Step Synthesis of Multisubstituted Pyrroles. Iran J Sci Technol Trans Sci 43, 2213–2218 (2019). https://doi.org/10.1007/s40995-018-0657-y
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DOI: https://doi.org/10.1007/s40995-018-0657-y