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Hybrid ceramics-based cancer theranostics

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Abstract

Cancer is a major threat to human lives. Early detection and precisely targeted therapy/therapies for cancer is the most effective way to reduce the difficulties (e.g., side effects, low survival rate, etc.) in treating cancer. To enable effective cancer detection and treatment, ceramic biomaterials have been intensively and extensively investigated owing to their good biocompatibility, high bioactivity, suitable biodegradability and other distinctive properties that are required for medical devices in oncology. Through hybridization with other materials and loading of imaging agents and therapeutic agents, nanobioceramics can form multifunctional nanodevices to simultaneously provide diagnostic and therapeutic functions for cancer patients, and these nanodevices are known as hybrid ceramics-based cancer theranostics. In this review, the recent developments of hybrid ceramics-based cancer theranostics, which include the key aspects such as their preparation, biological evaluation and applications, are summarized and discussed. The challenges and future perspectives for the clinical translation of hybrid ceramics-based cancer theranostics are also discussed. It is believed that the potential of hybrid ceramic nanoparticles as cancer theranostics is high and that the future of these theranostics is bright despite the difficulties along the way for their clinical translation.

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Acknowledgements

Q. Guan thanks The University of Hong Kong (HKU) for awarding her with a PhD scholarship for conducting research on developing new theranostics at HKU. Micrographs used in several figures in this article came from Q. Guan’s PhD research at HKU. The research on theranostics in M. Wang’s group was supported by grants from HKU and from the Research Grants Council (RGC) of Hong Kong, as well as by a donor in Hong Kong through her generous donation to support M. Wang’s research in biomaterials and tissue engineering. Assistance provided by members of M. Wang’s research group at HKU and by technical staff in HKU’s Electron Microscopy Unit and Department of Mechanical Engineering is acknowledged.

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Authors and Affiliations

  1. Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China

    Qingwen Guan & Min Wang

  2. Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen, China

    Qingwen Guan & Binbin He

  3. Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK

    Jie Huang

  4. Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, New York, NY, 10027, USA

    Helen H. Lu

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  1. Qingwen Guan
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  2. Binbin He
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  3. Jie Huang
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  5. Min Wang
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Contributions

QG and MW: research and design of the review; QG and BH: research and drafting of the manuscript; JH, HHL and MW: writing, reviewing and editing.

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Correspondence to Min Wang.

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Guan, Q., He, B., Huang, J. et al. Hybrid ceramics-based cancer theranostics. J. Korean Ceram. Soc. 59, 401–426 (2022). https://doi.org/10.1007/s43207-022-00217-w

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