The mode of action and the mechanism of resistance to antimalarial drugs
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Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway
2019, Bioorganic and Medicinal ChemistryCitation Excerpt :Among the different Plasmodium species, the Plasmodium falciparum is responsible for causing the most brutal Malaria.2 The urge of new efforts in medicinal and molecular studies of the malarial parasite was triggered by fast resistance developed by P. falciparum strains to available antimalarial drugs;3–6 and the decreased efficacy of malarial vaccines.7 This ever developing resistance of the strain against the available antimalarial drugs motivated medicinal chemists to develop a newer class of molecules which tend to inhibit various key enzymes involved in the lifecycle of the parasite.8
The prevalence of molecular markers of drug resistance in Plasmodium vivax from the border regions of Thailand in 2008 and 2014
2018, International Journal for Parasitology: Drugs and Drug ResistanceNot ordinary antimalarial drugs: Madagascar plant decoctions potentiating the chloroquine action against Plasmodium parasites
2017, Industrial Crops and ProductsNovel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition
2017, European Journal of Medicinal ChemistryCitation Excerpt :Malaria is caused by different parasites of Plasmodium, of which Plasmodium falciparum is the most vicious one [2]. The rapid emergence of P. falciparum strains resistant to currently available antimalarial drugs [3–6]; and the inefficacy of malarial vaccines [7] have alarmed the emergence to stimulate new efforts regarding medical and molecular studies about malaria. The resistance of the strain against the available antimalarial drugs and an urge for development of newer class of antimalarials has motivated the medicinal chemists towards design of inhibitors of various key enzymes involved in the lifecycle of the parasite [8].
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