Fundamental mechanisms of action of calcium antagonists in myocardial ischemia☆
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2013, European Journal of PharmacologyCitation Excerpt :Such an action would normally be expected to result in decreased contractility both in cardiomyocytes and multicellular preparations (Grantham and Cannel, 1996). Since reduced cardiac contractility can decrease myocardial oxygen consumption thereby leading to energy sparing effects, CAPE-induced moderate negative inotropy may be protective during ischemic conditions as shown for other Ca2+ antagonists (Nayler et al., 1987). Myocardial reperfusion following ischemia often causes myocardial injury and malignant ventricular arrhythmias.
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This study was supported by grants from the National Health and Medical Research Council of Australia and the Australian Tobacco Foundation.
Copyright © 1987 Published by Elsevier Inc.