Prevalence of risk factors in men with premature coronary artery disease☆
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2015, Atherosclerosis SupplementsCitation Excerpt :Although low HDL-c is predictive of increased CV risk, the complexity of its metabolic interrelationship with additional risk factors (e.g. LDL-c and triglyceride levels) must be considered. The prevalence of low HDL-c and high triglyceride levels in patients with proven CV disease has been evaluated in a number of studies and shows the importance of AD as a potential CV risk factor [20,21]. Furthermore, data from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myo cardial Infarction), ACCORD-Lipid (Action to Control Cardio vascular Risk in Diabetes), IDEAL (Incremental Decrease in End Points through Aggressive Lipid Lower ing) and TNT (Treating to New Targets) studies demonstrate that higher triglyceride levels are associated with higher rates of death and major CV events [22,23].
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This study was supported by Grant HL 35243 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, and by Contract 53-3K06-5-10 from the U.S. Department of Agriculture Research Service, Washington, D.C. Dr. Genest was supported by a Fellowship of the Medical Research Council of Canada, Ottawa, Ontario, Canada.