Spontaneous Regression (Autoinfarction) of Proliferative Sickle Retinopathy
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2010, Survey of OphthalmologyCitation Excerpt :This may be partly explained by the frequency of spontaneous regression through the development of atrophic or autoinfarcted lesions, which is recognized as a frequent and important determinant of the natural history of PSR. Regression has been documented by serial angiography 38,149,168 and is more common in SS-type than in SC-type disease.38 Probable mechanisms that contribute to spontaneous regression include changes in pigment epithelial growth factor (PEDF)/VEGF regulation.114
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This study was supported in part by contract NIH72 2956B and IP 18 HL 15168-03 from the National Heart and Lung Institute, Bethesda, Maryland.
Reprint requests to Morton F. Goldberg, M.D., University of Illinois Eye and Ear Infirmary, 1855 W. Taylor St., Chicago, IL 60612.