In vivo release of 5-HT in the lateral ventricle of the rat: effects of 5-hydroxytryptophan and tryptophan
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Cited by (77)
L-tryptophan administration and increase in cerebral serotonin levels: Systematic review
2018, European Journal of PharmacologyInteractive effect of light colours and temporal synergism of circadian neural oscillations in reproductive regulation of Japanese quail
2016, Journal of Photochemistry and Photobiology B: BiologyCitation Excerpt :Based on this assumption, six different temporal phase relation of serotonergic and dopaminergic oscillations were induced by administering the serotonin precursor 5-hydroxytryptophan (5-HTP) and dopamine precursor l-dihydroxyphenylalanine (l-DOPA) at intervals of 0, 4, 8, 12, 16 and 20 hrs establishing 0-h, 4-h, 8-h, 12-h, 16-h and 20-h phase relation between the two neural oscillations. Since serotonin and dopamine do not cross the blood brain barrier but their precursors (5-HTP and l-DOPA respectively) do cross and are converted to neurotransmitters (serotonin and dopamine respectively) by appropriate neurons of the brain, systemic injections of 5-HTP and l-DOPA were given instead of serotonin and dopamine injections respectively [48,51]. This protocol resulted in the suppression of gonadal growth in 8-h and stimulated reproductive performance in 12-h quail, while other time relations were found to be ineffective [9,13].
Influence of temporal relationships between serotonergic and dopaminergic precursors on the regulation of gonadal development in birds
2012, General and Comparative EndocrinologyCitation Excerpt :After the treatment, all the experimental and control groups were transferred to required photoperiodic conditions (natural day length-NDL, long day length or short day length) and biweekly observations (reproductive/metabolic indices) were taken until the termination of study (30–150 days post treatment). Since serotonin and dopamine do not cross the blood brain barrier but their precursors do cross and are converted to neurotransmitters by appropriate neurons of the brain, hence systemic injections of 5-HTP and L-DOPA were given instead of serotonin and dopamine, respectively (Shindo et al., 1973; Ternaux et al., 1975). Following part of the review is focused on some experimental findings in different species of birds.
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