Elsevier

Brain Research

Volume 304, Issue 2, 25 June 1984, Pages 383-386
Brain Research

The nerves to blood vessels supplying blood to nerves: the innervation of vasa nervorum

https://doi.org/10.1016/0006-8993(84)90344-5Get rights and content

Abstract

Noradrenergic, serotoninergic and peptidergic nerves have been demonstrated in perivascular plexuses of vasa nervorum of sympathetic, parasympathetic and somatic nerve trunks. 5-Hydroxytryptamine-, vasoactive intestinal polypeptude- and substance P-containing fibers were found by immunohistochemistry to variable extents in whole mounts of the epineurium of sciatic, vagus and paravertebral sympathetic chains of rabbits. Innervation increased with age. This suggests an hitherto unsuspected role for these vasoactive substances in normal blood flow to nerves and in the genesis of experimental and human neuropathies.

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Supported in part by The Medical Research Council (U.K.) and New Mexico Health Enhancement and Marathon Clinics Research Fund.

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