Elsevier

Brain Research

Volume 375, Issue 2, 11 June 1986, Pages 373-376
Brain Research

Autoradiographic localization of angiotensin receptors in the sheep brain

https://doi.org/10.1016/0006-8993(86)90761-4Get rights and content

Abstract

Binding of [125I]-(Sar1, Ile8)angiotensin II (AII) to frozen sections of sheep brain was determined by in vitro autoradiography. Greatest AII-binding occurred in the organum vasculosum of the lamina terminalis, subfornical organ, median preoptic and periventricular nuclei situated in the anterior third ventricle wall. Other binding sites included the hypothalamic supraoptic and paraventricular nuclei and the medullary nucleus tractus solitarius. These regions may be central receptor sites for AII involvement in fluid and electrolyte balance and blood pressure regulation.

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    Structures along the lamina terminalis, such as the median preoptic nucleus (MnPO) and the organum vasculosum of the lamina terminalis (OVLT), play an essential role in the neural control of body fluid homeostasis and are responsive to AngII. The MnPO and OVLT express AT1 receptors [17–20], and lesions made in the anteroventral third ventricle (AV3V) region, which comprises parts of the MnPO and OVLT, abolish the drinking response to icv AngII [21]. Moreover, c-Fos expression is observed in the AV3V after icv injection of AngII [22,23], and ventricular obstruction that prevents CSF from reaching the AV3V prevents water intake stimulated by AngII injected into the lateral ventricle [21,24–26].

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This work was supported by grants from the National Health and Medical Research Council of Australia, the Austin Hospital Research Foundation and the Robert J. Jr. and Helen C. Kleberg Foundation.

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