Modulation of cortical neuronal activity by a serotonergic agent: a PET study in humans
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2015, NeuroImageCitation Excerpt :Thalamic sites are richly innervated by serotonergic neurons from the raphe nuclei via different pathways (Parent, 1981; Lavoie and Parent, 1991; Gurevich and Joyce, 1996). In line with our results, several studies have reported decreased thalamic glucose metabolism and blood flow after (albeit acute) infusion of SSRIs and have linked this to effects of the drugs at serotonergic sites (Kapur etal., 1994; Meyer etal., 1998; Smith and Geday, 2001; Smith etal., 2002). By contrast, the weakly positive modulations of the amygdala and insula are not supported by perfusion imaging studies of depressive disorders, looking at the amygdala in particular because of its key role in processing emotional stimuli.
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