Elsevier

Brain Research

Volume 681, Issues 1–2, 29 May 1995, Pages 223-228
Brain Research

Crowding stress impairs the pituitary-adrenocortical responsiveness to the vasopressin but not corticotropin-releasing hormone stimulation

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Abstract

To evaluate the effect of social crowding stress on the CRH and vasopressin-induced hypothalamic-pituitary-adrenocortical (HPA) response, both those neuropeptides were administered intracerebroventricularly and intraperitoneally to rats crowded for 3 days. Crowding stress did not affect the corticosterone response to CRH given by either route (1 μg i.c.v. or 2 μg/kg i.p.) but totally abolished or considerably diminished the response to vasopressin given i.p. (5 μg/kg) or i.c.v. (5 μg), respectively. Social crowding stress considerably impairs central vasopressin but does not change the CRH-system involved in the HPA stimulation.

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