An experimental model to investigate the dynamics of wound contraction

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Abstract

An excisional wound model in the Hooded Lister rat is described. The methods used to inflict, measure and characterise the process of wound contraction are comprehensively discussed. The model is shown to be reliable, reproducible and capable of detecting the effect of systemically administered prednisolone.

References (73)

  • SnowdenJ.M.

    Wound closure: an analysis of the relative contributions of contraction and epithelialization

    J Surg Res

    (1984)
  • HuntT.K. et al.

    Oxygen and healing

    Am J Surg

    (1969)
  • CattyR.H.C.

    Healing and contraction of experimental fullthickness wounds in the human

    Br J Surg

    (1965)
  • HienN.T. et al.

    Facilitated wound healing using transparent film dressing following Mohs micrographic surgery

    Arch Dermatol

    (1988)
  • PoriesW.J. et al.

    The measurement of human wound healing

    Surgery

    (1966)
  • RamirezA.T. et al.

    Experimental wound healing in man

    Surg Gynecol Obstet

    (1969)
  • BaronH.

    Der Einfluss des physikalisch and chemisch bedingten Milieus auf die Wundheilung insbesondere auf die Wirungsweise au¨sserlich angewendten Penicillins

    Arzneimittelforschung

    (1955)
  • CarrelA.

    The treatment of wounds

    JAMA

    (1910)
  • Lecomte Du NouyP.

    Cicatrization of wounds Z. A general equation for the law of cicatrization of surface wounds

    J Exp Med

    (1919)
  • NowinskiW.W. et al.

    Tricar☐ylic acid cycle in wound healing by granulation

  • AbercrombieM. et al.

    Wound contraction in rabbit skin studied by splinting the wound margins

    J Anat

    (1960)
  • BillinghamR.E. et al.

    Studies on wound healing, with special reference to the phenomenon of contracture in experimental wounds in rabbits' skin

    Ann Surg

    (1956)
  • FranklinJ.D. et al.

    Effects of topical applications of epidermal growth factor on wound healing

    Plast Reconstr Surg

    (1979)
  • HeiteH.J.

    Ein tierexperimentelles Modell zur quantitativen Pru¨fung wundheilungs fo¨rdernder Salben

    Arzneimittelforschung

    (1955)
  • HowesE.L. et al.

    Retardation of wound healing by cortisone

    Surgery

    (1950)
  • LelcukS. et al.

    Prostacyclin (PGI2) and throm☐ane (TXA2): mediation of wound healing

    Isr J Med Sci

    (1987)
  • JosephJ. et al.

    The healing of defects in immobile skin in rabbits

    Br J Surg

    (1961)
  • HuntT.K. et al.

    Effect of vitamin A on reversing the inhibitory effect of cortisone on healing of open wounds in animals and man

    Ann Surg

    (1969)
  • AbercrombieM. et al.

    Collagen formation and wound contraction during repair of small excised wounds in the skin of rats

    J Embryol Exp Morph

    (1954)
  • HigtonD.I.R. et al.

    The force of contraction of full thickness wounds of rabbit skin

    Br J Surg

    (1964)
  • SeyleH. et al.

    Acceleration and inhibition of wound healing by topical treatment with different types of inflammatory irritants

    Am J Surg

    (1969)
  • SnowdenJ.M.

    Wound contraction. A quantitative interpretation

    Aust J Exp Biol Med Sci

    (1981)
  • YoungJ.S. et al.

    Some observations on the healing of experimental wounds in the skin of the rabbit

    J Path Bact

    (1941)
  • SnowdenJ.M. et al.

    Wound contraction, the effects of scab formation and the nature of the wound bed

    Aust J Exp Biol Med Sci

    (1982)
  • AbercrombieM. et al.

    Wound contraction in relation to collagen formation in scorbutic guinea pigs

    J Embryol Exp Morph

    (1956)
  • CharltonC.A.C. et al.

    Wound contraction in the guinea pig

    Br J Surg

    (1961)

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