An experimental model to investigate the dynamics of wound contraction
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Small animal models of thermal injury
2022, Methods in Cell BiologyCitation Excerpt :While many studies use male rats due to cost consideration, estrogen deficiency detrimentally impacts wound healing (Pirila, Parikka, Ramamurthy, et al., 2002). Additionally, male rats have a greater tendency toward healing by epithelialization while females have thinner skin and a higher wound contraction rate, potentially confounding results and necessitating standardization (Cross, Naylor, Coleman, & Teo, 1995). Despite these shortcomings, rodents are routinely applied as a means to study metabolic phenomena and wound healing in the context of burns (Abdullahi et al., 2014).
Acellular dermal matrix in skin wound healing in rabbits – histological and histomorphometric analyses
2021, ClinicsCitation Excerpt :Biocompatible matrices can simulate the extracellular matrix of native tissue, providing a porous structure and an environment favorable to cell growth, proliferation and differentiation, which are partly responsible for wound healing (22). The selection of the number and position of the lesions followed the model established by Cross et al. (24). The number of biopsies is justified for the use of as few animals as possible, and the selected days were determined to follow the progression of wound healing.
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