Changes in factor VIII activity and Von Willebrand factor antigen concentration with age in dogs

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Abstract

The factor VIII activity of 38 German shepherd puppies, 6–12 weeks old, submitted for diagnosis of haemophilia A was measured. Eight of these puppies had values higher than would be expected for haemophiliacs, but less than the reference range for adult dogs. A further sequential study of 21 puppies (6–26 weeks of age) indicated that the factor VIII activity of puppies is generally less than that of adult dogs until about 14 weeks of age. Changes in the concentration of von Willebrand factor antigen in the puppies were irregular. These variations are probably not sufficient to interfere with accurate diagnosis of haemophilia A in most affected young dogs, but may interfere with the detection of heterozygotes in young bitches.

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    The VWD in DD/GWP was Type 2 as it was possible to demonstrate both the lacking of high molecular weight VWF multimers and the autosomal recessive inheritance. In addition, Brooks et al. (2001) established that the concentration of VWF in DD/GWP was inherited and predictable in the litters regardless of temporal variation, pregnancy and hormonal factors, and variation due to sampling artifacts as previously reported in the interpretation of VWF values in VWD (Mansell and Parry, 1991, 1992; Panciera and Johnson, 1994; Moser et al., 1996a, 1998; Brooks et al., 2001). It is important here to describe shortly the origin and the relationship between the two breeds, as GSP and DD/GWP are both affected by Type 2 VWD.

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