The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment

doi:10.1016/0008-8749(81)90368-3

Cellular Immunology

Volume 61, Issue 1, June 1981, Pages 220-224

https://doi.org/10.1016/0008-8749(81)90368-3 Get rights and content

Abstract

Immunologically naive C57BL/6J(B6, H-2K^bD^b) T cells can, after negative selection in vivo to remove alloreactive lymphocytes, be induced to respond to H-2K^k-vaccinia virus when primed in irradiated B10.A(4R) (H-2K^kD^b) recipients. Precursors with the capacity to generate cytotoxic T-lymphocyte (CTL) effector function specific for H-2K^k-vaccinia virus are present in the long-lived, recirculating T-cell pool. However, prior priming of the B6(H-2^b) mice with vaccinia virus abrogates the responder potential of the H-2^b CTL for H-2K^k-vaccinia virus. Furthermore, addition of primed to unprimed H-2^b T cells greatly diminishes the response of the naive lymphocyte populations. A possible mechanism for this suppression is that the expanded pool of memory CTL specific for H-2D^b-vaccinia virus eliminates the resident B10.A(4R) stimulator cells before the primary response to H-2K^k-vaccinia virus is sufficiently developed.

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^☆: This work was funded by Grants AI-14162 and AI-15412 from the National Institute for Allergy and Infectious Diseases.

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Short communicationThe response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment☆

Abstract

J. Exp. Med

J. Exp. Med

Short communication
The response to H-2-different virus-infected cells is mediated by long-lived T lymphocytes and is diminished by prior virus priming in a syngeneic environment☆