ATP as a co-transmitter in rat tail artery
References (16)
- et al.
Contribution by purines to the neurogenic response of the vas deferens of the guinea-pig
European J. Pharmacol.
(1981) - et al.
An electrophysiological analysis of the effects of noradrenaline and alpha-receptor antagonists on neuromuscular transmission in mammalian muscular arteries
Br. J. Pharmacol.
(1980) - et al.
Evidence that ATP acts as a cotransmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens
European J. Pharmacol.
(1983) - et al.
Inhibition of excitatory junction potentials in guinea-pig vas deferens by α,β-methylene ATP: Further evidence for ATP and noradrenaline as cotransmitters
European J. Pharmacol.
(1984) - et al.
The postjunctional effects and neural release of purine compounds in the guinea-pig vas deferens
European J. Pharmacol.
(1978) - et al.
Inhibition of postganglionic motor transmission in vas deferens by indirectly acting sympathomimetic drugs
J. Physiol. (London)
(1972) - et al.
Evidence against adrenergic motor transmission in the guinea-pig vas deferens
J. Physiol. (London)
(1971) Two components in the cellular response of rat tail arteries to nerve stimulation
J. Physiol. (London)
(1982)
Cited by (258)
ATP as a cotransmitter in sympathetic and parasympathetic nerves - another Burnstock legacy
2021, Autonomic Neuroscience: Basic and ClinicalNeurotransmitters responsible for purinergic motor neurotransmission and regulation of GI motility
2021, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :These observations were confirmed by experiments on rat tail arteries. Electrophysiological responses to nerve stimulation were biphasic and consisted of a fast transient depolarization followed by a much slower and prolonged depolarization (Sneddon and Burnstock, 1984). α,β-methylene adenosine 5′ triphosphate, used to desensitize P2 receptors, blocked the initial fast depolarization but did not affect the slow phase.
The inevitability of ATP as a transmitter in the carotid body
2021, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :The SCG, a sympathetic ganglion that lies juxtaposed to the CBs, richly innervates the vasculature surrounding the glomus tissue with evidence for a small number of pre- and post-ganglionic sympathetic fibres that directly append glomus clusters (McDonald and Mitchell, 1975; Verna et al., 1984; Vázquez-Nin et al., 1978; Atanasova et al., 2016). The co-release of ATP with noradrenaline from sympathetic synaptic terminals has been well described (Sneddon and Burnstock, 1984; Burnstock, 1990; Tompkins and Parsons, 2006; Gourine et al., 2009), yet whether sympathetic sources contribute significantly to eATP signalling in the CB, or rather modulates ganglionic outputs directly (Takaki et al., 2015) is not known. One might consider, however, that sympathetic overactivity may directly affect the CB blood supply through vasoconstriction, and the release of ATP from varicosities could also induce or exacerbate systemic and/or local inflammation which may also alter plasma eATP concentrations (Norman et al., 1985; Harrison, 2014).
History of Geoff Burnstock's research on P2 receptors
2021, Biochemical PharmacologySympathetic innervation of the kidney in health and disease: Emphasis on the role of purinergic cotransmission
2017, Autonomic Neuroscience: Basic and ClinicalATP as a cotransmitter in the autonomic nervous system
2015, Autonomic Neuroscience: Basic and ClinicalCitation Excerpt :In contrast, ATP evokes rapid, transient depolarisations or inward currents when cells are held under voltage-clamp, with a time-course that mimics that of ejps (see Evans and Kennedy, 1994; McLaren et al., 1998b; Sneddon et al., 1996 and references therein). Although several explanations were proposed to explain how NA could nonetheless mediate ejps, the debate ended when ejps in the guinea-pig vas deferens were clearly demonstrated to be inhibited by desensitisation of the P2X1 receptor by α,β-meATP (Sneddon and Burnstock, 1984), then by suramin (Sneddon, 1992) and PPADS (McLaren et al., 1994). Subsequently, Sneddon et al. (2000) showed that the selective P2X1 antagonist, NF023, depressed ejps in a rapid, concentration-dependent and reversible manner (Fig. 4).
- ∗
Present address: Department of Physiology and Pharmacology, Royal College, Strathclyde University, George Str., Glasgow, G.I., U.K.