ATP as a co-transmitter in rat tail artery

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Abstract

In rat tail artery the electrical response to nerve stimulation was biphasic, consisting of a fast, transient depolarisation which was resistant to α-adrenoceptor antagonists and a slow, prolonged depolarisation which was abolished by them. In the presence of α,β-methylene-adenosine 5′-triphosphate (α,β-methylene-ATP), which abolishes responses mediated via P2-purinoceptors, the fast depolarisation was abolished, whilst the slow depolarisation persisted. We propose that both adenosine 5′-triphosphate (ATP) and noradrenaline (NA) are involved in sympathetic neurotransmission in the rat tail artery.

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    These observations were confirmed by experiments on rat tail arteries. Electrophysiological responses to nerve stimulation were biphasic and consisted of a fast transient depolarization followed by a much slower and prolonged depolarization (Sneddon and Burnstock, 1984). α,β-methylene adenosine 5′ triphosphate, used to desensitize P2 receptors, blocked the initial fast depolarization but did not affect the slow phase.

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Present address: Department of Physiology and Pharmacology, Royal College, Strathclyde University, George Str., Glasgow, G.I., U.K.

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