Evidence that 5-HT2 receptors predominantly mediate the contraction of the rat basilar artery to 5-hydroxytryptamine
References (36)
Basilar arlery migraine
Lancet
(1961)- et al.
Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine
Neuropharmacology
(1986) - et al.
The 5-HT4 receptor: naughty hut nice
Trends Pharmacol. Sci.
(1989) - et al.
Possible benefit of GR 43175 a novel 5-HT1-like receptor agonist, for the acute treatment of severe migraine
Lancet
(1988) - et al.
Immunohistochemical demonstration of serotonin in nerves supplying human cerebral and mesenteric blood vessels
Lancet
(1983) - et al.
Serolonin as a neurotransmitter in cerebral arteries
Brain Res.
(1982) - et al.
8-Hydroxy-2(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site
Eur. J. Pharmacol.
(1983) - et al.
The binding of serolonergic ligand to the porcine choroid plexus: characterization of a new type of serotonin recognition site
Eur. J. Pharmacol.
(1984) - et al.
Neurochemical studies on the existence, origin and characteristics of the serotonergic innervation of small pial vessels
Brain Res.
(1985) - et al.
Some quantitative uses of drug antagonists
Br. J. Pharmacol.
(1959)
Differential vasomolor action of noradrenaline. serolonin and histamine in isolated basilar artery from rat and guinea-pig
Acta Physiol. Scand.
Cerehrovascular serolonergic receptors mediating vasoconstriction: further evidence for the existence of 5-HT2 receptors in rat and 5-HT1-like receptors in guinea-pig basilar arteries
Acta Physiol. Scand.
Relationship between receptors mediating serotonin (5-HT) contractions in the canine basilar artery to 5-HT1, 5-HT2 and the rat stomach fundus 5-HT receptors
J. Pharmacol. Exp. Ther.
Influence of the endothelium on contractile effects of 5-hydroxytryptamine and selective 5-HT agonists in canine hasilar artery
Br. J. Pharmacol.
Characterization of 5-HT receplors mediating contraction of canine and primate basilar artery by use of GR 43175, a selective 5-HT1-like receptor agonist
Br. J. Pharmacol.
Central serotonergic nerves project to the pial vessels of the brain
Nature
Spinal noradrenergic pathways presser responses to central angiotensin II
Am. J. Physiol.
Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites
Naunyn-Schmiedeb. Arch. Pharmacol.
Cited by (14)
Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery
2012, European Journal of PharmacologyCitation Excerpt :Sumatriptan was a more potent vasoconstrictor in human middle meningeal (pEC50=7.0), porcine middle cerebral artery (pEC50=6.55±0.1) and bovine isolated middle cerebral artery (pD2=6.0±0.2) than the potency of the drug in the rat middle cerebral artery (Razzaque et al., 2002; Nagai et al., 2007; Roon et al., 1999). Our results are in agreement with those of Hansen-Schwartz et al. (2003b), who obtained contractile responses to sumatriptan at high concentrations in the rat middle cerebral artery using the same method also applied by us, and other authors also described that sumatriptan is a low potency vasoconstrictor in rat cerebral arteries (Limmroth et al., 1999; Deckert and Angus, 1992). These results fit with weak binding of sumatriptan (Ki=0.5 μM) to the rat 5-HT1B receptor (Adham et al., 1992).
Characterization of 5-hydroxytryptamine-induced contraction and acetylcholine-induced relaxation in isolated chicken basilar artery
2012, Poultry ScienceCitation Excerpt :Two 5-HT receptor subtypes in basilar arteries have been recognized, and the nature of these subtypes has been reported to differ in various animal species. The 5-HT-induced contraction of the basilar artery is mediated via activation of 5-HT1 receptors in snakes (Yoshinaga et al., 2007), guinea pigs (Chang and Owman, 1989), rabbits (Seager et al., 1992), and humans (Parsons et al., 1989); 5-HT2 receptors in rats (Chang and Owman, 1989; Deckert and Angus, 1992) and monkeys (Cercopithecus aethiops; Chang et al., 1987); and both 5-HT1 and 5-HT2 receptors in dogs (Connor et al., 1989), horses (Miyamoto et. al., 1996), sheep (Gaw et al., 1990), pigs (Miyamoto et. al., 1994), and monkeys (Macaca fascicularis; Connor et al., 1989). In porcine pulmonary arteries, 5-HT induced relaxation (Cocks and Angus, 1983).
Innervation of cerebral arteries by nerves containing 5-hydroxytryptamine and noradrenaline
1995, Pharmacology and TherapeuticsEndothelial thromboxane production plays a role in the contraction caused by 5-hydroxytryptamine in rat basilar arteries
1993, European Journal of Pharmacology5-HT<inf>2B</inf> Receptor, the Heart and Blood Vessels
2021, Receptors
- 1
Present address: Laboratories Fournier, 50 Rue de Dijon, B.P. 90. 21121 Daix, France.