Identification and cDNA cloning of two novel low molecular weight host-protective antigens from Taenia ovis oncospheres
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Cited by (57)
Advances in the treatment, diagnosis, control and scientific understanding of taeniid cestode parasite infections over the past 50 years
2021, International Journal for ParasitologyGeneration and application of a monoclonal antibody against the 18-kDa oncosphere antigen of Taenia pisiformis
2021, Experimental ParasitologyCombined use of two separate but protective vaccine antigens provides protection against Taenia ovis infection in lambs in the presence of protective maternal antibody
2021, VaccineCitation Excerpt :Further evidence for the important role played by complement-fixing antibodies in protection against T. ovis is provided by these antibodies being lethal for T. ovis oncospheres in in vitro culture [8]. Protection of sheep against infection with eggs of T. ovis can be achieved by vaccination with recombinant antigens cloned from oncosphere mRNA [9,10]. High levels of protection by vaccination have been demonstrated against both artificial and naturally-acquired infection [11].
Engineering DNA vaccines against infectious diseases
2018, Acta BiomaterialiaCitation Excerpt :Cons: adjuvants that are commonly used including alum and calcium salts can cause severe inflammation and are not compatible with, or advantageous for, certain antigens [39]. With continual improvements in DNA sequencing technology, we can better understand key conserved sequences that can be transcribed and translated into antigens and discover or engineer sequences that may be used for protection (i.e., TSOL18 [40–42]). Nucleic acid code can be mass produced by DNA recombinant technology, and these codes can be directly delivered and subsequently processed and displayed by APCs for eventual seroconversion by the patient’s own transcription and translation machinery.
Synergetic effect of Egyptian propolis in immunization of BALB/c mice against bovine cysticercosis
2015, Asian Pacific Journal of Tropical BiomedicineImmune responses to a recombinant attenuated Salmonella typhimurium strain expressing a Taenia solium oncosphere antigen TSOL18
2013, Comparative Immunology, Microbiology and Infectious DiseasesCitation Excerpt :Previous animal vaccination experiments using defined proteins, synthetic peptides, recombinant phages, and plasmid DNA have resulted in different levels of protection against experimental T. solium infection [6–11]. A gene encoding T. solium oncosphere antigen TSOL18, a homologue to Taenia ovis To18 [12] and T. saginata TSA18 [13] that induced protective responses in immunized sheep and cattle, respectively, was screened out from a cDNA expression library of T. solium oncospheres [14]. The TSOL18 antigen had been confirmed the existence of a secretory signal at the N terminal and at least one structural domain of Fibronectin III (Fn III) at the C terminal, which is likely to be involved in interactions between oncospheres and intermediate hosts and seems important in inducing host immune protection [15].
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Present addresses: AgResearch, NZ Pastoral Agriculture Research Institute Ltd, Wallaceville Animal Research Centre, P.O. Box 40063, Upper Hutt, New Zealand.
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Present addresses: CSIRO Division of Animal Health, Private Bag No. 1, Parkville, Victoria 3052, Australia