Liquid chromatography-mass spectrometryMass spectral analyses of microcystins from toxic cyanobacteria using on-line chromatographic and electrophoretic separations☆
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Cited by (123)
Research progress in the functionalization of microcystin-LR based on interdisciplinary technologies
2021, Coordination Chemistry ReviewsMicrocystin biosynthesis and toxic effects
2021, Algal ResearchEffects of arginine on the growth and microcystin-LR production of Microcystis aeruginosa in culture
2019, Science of the Total EnvironmentCitation Excerpt :Therefore, the methods of analysis capable of identifying different analogues concurrently are necessary. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) is a powerful method for MC quantification and structural characterization although few studies apply LC-MS/MS analysis to stable-isotope-labeled MCs (Bateman et al., 1995). It is concluded after LC-MS/MS analysis that 15N from ammonia is probably incorporated into the Arg residue.
The biosynthesis of <sup>15</sup>N-labeled microcystins and the comparative MS/MS fragmentation of natural abundance and their <sup>15</sup>N-labeled congeners using LC-MS/MS
2018, ToxiconCitation Excerpt :Until recently, the limitation to SIDA for microcystin quantitation has been the availability and cost of isotopically labelled material (Beach et al., 2016). Small scale production of 15N-enriched microcystins was reported for analytical methodologies over two decades ago (Bateman et al., 1995) and again recently in small scale for the purpose of SIDA (Sano et al., 2011). As algal bloom events continue to rise worldwide and research on MC accumulation and toxicity in various model systems expands, the need for accurate and sensitive quantitation of MC congeners is becoming increasingly paramount.
Fabricating photoelectrochemical aptasensor for selectively monitoring microcystin-LR residues in fish based on visible light-responsive BiOBr nanoflakes/N-doped graphene photoelectrode
2016, Biosensors and BioelectronicsCitation Excerpt :Considering that more than 80 isoforms of MCs have been identified, it is hard to discriminate these structurally similar microcystin congeners, and their performances are limited by the high matrix effect when developing sensitive and specific methods for detecting MC-LR (Eissa et al., 2014). Many analytical techniques have been utilized for MC-LR detection, including chromatography (Falconer, 1993), liquid chromatography/mass spectrometry (LC-MS) (Li et al., 2014), capillary electrophoresis (Bateman et al., 1995), Raman spectroscopy (Saito et al., 2008), and protein phosphatase inhibition assays (Ma et al., 2009; Zhang et al., 2010a). Whereas these methods provide good sensitivity, they usually require highly qualified personnel, bulky apparatus, high cost, and time-consuming process.
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