Experimental louping-ill in sheep and lambs: II. Neuropathology
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2019, Large Animal Internal MedicineA Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus
2018, Journal of Comparative PathologyCitation Excerpt :The relative paucity of clinical signs in the present case is typical of animals that succumb in the acute phase of the disease, 5–7 days post infection (Doherty and Reid, 1971a, 1971b). The morphology, number and distribution of the brain lesions are consistent with those found in sheep with LI (Doherty and Reid, 1971a, 1971b) and also in several other species (MacAldowie et al., 2005; Benavides et al., 2011). Additionally, the total lack of immunolabelling of LIV in any tissue except the central nervous system, together with the limited immunolabelling within the brain, is not inconsistent with ovine clinical field cases (M. Dagleish, personal observations) and previous experimental studies in sheep, as large amounts of LIV antigen are usually found by IHC only in the peracute stage of disease (Reid and Doherty, 1971a).
120 years of Louping-ill Research: an Historical Perspective from the Archive of the Journal of Comparative Pathology
2017, Journal of Comparative PathologyVaccination against Louping Ill Virus Protects Goats from Experimental Challenge with Spanish Goat Encephalitis Virus
2017, Journal of Comparative PathologyCitation Excerpt :Naturally acquired SGEV infection caused a 100% mortality rate in clinically affected goats (Balseiro et al., 2012) and although the challenge isolate used for this study was derived from that original natural outbreak, no fatalities occurred in this study. This was despite the induction of histological lesions in the CNS in all animals in the positive control group and 5/9 of these animals developing neurological clinical signs, all of which is similar to experimental infection of sheep with LIV (Doherty and Reid, 1971a; Reid et al., 1984; Sheahan et al., 2002). This difference in mortality rate between the naturally acquired and experimentally induced disease may be due to a number of factors.
Lambs are Susceptible to Experimental Challenge with Spanish Goat Encephalitis Virus
2017, Journal of Comparative PathologyCitation Excerpt :Subcutaneous challenge with SGEV in goats resulted in 5/9 animals developing neurological clinical signs (Salinas et al., 2017), in contrast to only 3/9 lambs in this study. Experimental infections of sheep with LIV by the subcutaneous route at a similar, lower than one log, challenge dose (2.5 × 106–106.6 PFU/animal) resulted in 2/8 sheep developing neurological clinical signs (Reid and Doherty, 1971; Doherty and Reid, 1971a), comparable with the results obtained in this study. These differences between the species could indicate a greater degree of susceptibility of goats than lambs to SGEV.