Prostacyclin and prostanoid modifiers aid ischemic skin flap survival
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Are prostaglandins or calcium channel blockers efficient for free flap salvage? A review of the literature
2018, Journal of Stomatology, Oral and Maxillofacial SurgeryCitation Excerpt :Knight et al. and Lepore et al. used the same model of epigastric free flap in rabbits. The free flaps were ex vivo stored at 25°C in saline-moistened gauze in a sealed sterile container for 21 hours and then revascularized by microvascular anastomoses to the contralateral side [9,10]. Knight et al. compared both in vivo systemic and local injection of physiologic serum in control group and prostaglandins after reperfusion.
In Vivo Observation of Leukocyte-Endothelium Interaction in Ischemia Reperfusion Injury With the Dorsal Window Chamber and the Effects of Pentoxifylline on Reperfusion Injury
2007, Journal of Surgical ResearchCitation Excerpt :Different therapeutic agents have been recommended to improve survival of revascularised free flaps. Anticoagulants (heparin, hirudin, dextran), thrombolytic agents (streptokinase, urokinase), anti-inflammatory agents (aspirin, ibuprofen), free radical scavengers (superoxide dismutase, catalase, deferoxamine, allopurinol), and vasodilators (Ca channel blockers, dipyridamole, adenosine) have been used mostly experimentally [30–38]. Only a few have been used in clinical setting.
Effects of prolonged hypoxia, reoxygenation, and shear stress on bovine aortic endothelial cell prostacyclin production
1998, Prostaglandins and Other Lipid MediatorsEffects of oxygen tension and shear stress on human endothelial cell prostacyclin production
1997, Journal of Surgical ResearchIloprost and salvage of a free flap
1996, British Journal of Plastic Surgery