A peptide-like substance from pituitary that acts like morphinePurification and properties
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Cited by (198)
Dynorphin and its role in alcohol use disorder
2020, Brain ResearchCitation Excerpt :The discovery of Dynorphin B (13 amino acids) or rimorphin followed, in conjunction with the c-terminus extended form of dynorphin B, Big Dynorphin and leumorphin (Fischli et al., 1982; Kilpatrick et al., 1982; see Ferré et al., 2019 for sequences). This was preceded by discovery of the endogenous morphine-like substances and opioid peptides methionine and leucine enkephalin (Cox et al., 1976, 1975; Goldstein et al., 1971; Hughes et al., 1975; Li and Chung, 1976; Teschemacher et al., 1975; Tperenius and Wahlström, 1975). This era has been fondly described as the ‘golden era of neuropeptide discovery’ (Chavkin, 2013) a critical period during which our understanding of neuropeptide function was enhanced following new methods of neuropeptide detection and purification.
Structure and dynamics of dynorphin peptide and its receptor
2019, Vitamins and HormonesCitation Excerpt :Dynorphin is an endogenous neuropeptide first isolated from porcine pituitary (Cox, Opheim, Teachemacher, & Goldstein, 1975) with a particularly potent opioid activity (Goldstein, Tachibana, Lowney, Hunkapiller, & Hood, 1979).
Endogenous morphine and its metabolites in mammals: History, synthesis, localization and perspectives
2013, NeuroscienceCitation Excerpt :These opioid receptors have seven transmembrane domains coupled to G proteins (for review: Kieffer and Evans, 2002, 2009; Trescot et al., 2008; Dietis et al., 2011; Al-Hasani and Bruchas, 2012; Feng et al., 2012). The presence of opioid receptors has led to the characterization of several endogenous ligands called opioids due to their peptidic nature: enkephalins (Hughes et al., 1975a,b; Simantov and Snyder, 1976), β-endorphin (Bradbury et al., 1976; Graf et al., 1976; Lazarus et al., 1976; Li and Chung, 1976; Li et al., 1976), dynorphin (Cox et al., 1975; Goldstein et al., 1979; Lowney et al., 1979), nociceptin/orphanin FQ (Meunier et al., 1995; Reinscheid et al., 1995) and endomorphins (Hackler et al., 1997; Zadina et al., 1997). In addition to endogenous opioid peptides, endogenous morphine-like molecules, which are known as endogenous opiates due to their alkaloid nature have been discovered (Gintzler et al., 1976a,b; Blume et al., 1977; Shorr et al., 1978).
Suicide neurobiology
2009, Progress in Neurobiology30 years of dynorphins - New insights on their functions in neuropsychiatric diseases
2009, Pharmacology and TherapeuticsDynorphin a
2007, xPharm: The Comprehensive Pharmacology Reference