Method for the rapid determination of norepinephrine, dopamine, and serotonin in the same brain region

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Abstract

A method is presented for the fluorometric analysis of norepinephrine, dopamine and serotonin. This procedure is a combination of an unpublished catecholamine assay developed by Hogans and of the o-phthaldialdehyde serotonin reaction reported by Maickel and Miller [9]. This procedure should greatly facilitate the correlation of neurotransmitter levels in brain regions with changes in behavior produced by experimental manipulations.

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2

Fellow, Foundations; Fund for Research Psychiatry Grant 72–536.

3

Present address: Departments of Pharmacology and Psychiatry, College of Medicine, University of Saskachewan, Saskatoon, Canada, S7N OWO.

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