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No change in neostriatal D-2 dopamine receptors after NMDA lesions of rat prefrontal cortex

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Abstract

D-2 dopamine receptor function in rat nucleus accumbens and anterior corpus striatum was examined 6–8 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Lesions failed to alter the affinity or density of D-2 receptors labelled by [3H]spiperone in membrane preparations of both subcortical areas. Locomotor activity and stereotyped behaviours induced by the D-2 agonist, LY-171555, were also not significantly altered in lesioned animals. These results suggest that D-2 dopamine receptors of nucleus accumbens and anterior corpus striatum are not localized on corticofugal afferents from medial prefrontal cortex.

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  • Cited by (4)

    1

    Present address: University of Melbourne, Department of Psychiatry, Royal Melbourne Hospital, Parkville, VIC 3052, Australia.

    2

    Present address: Neuropharmacology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.

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