Elsevier

The Lancet

Volume 342, Issue 8870, 28 August 1993, Pages 536-539
The Lancet

Hypothesis
Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs

https://doi.org/10.1016/0140-6736(93)91653-4Get rights and content

Abstract

The pathogenesis of rheumatoid arthritis and the mode of action of anti-rheumatic drugs are unknown. This hypothesis proposes that haemopoietic growth factors (colony stimulating factors [CSFs]) have an important role in rheumatoid arthritis as regulators of myelopoiesis and as activators of inflammatory leucocytes. It also suggests that slow-acting anti-rheumatic drugs may work by inhibiting myelopoiesis. This opposition to one of the actions of the CSFs would result in fewer inflammatory cells in the inflamed joints.

References (41)

  • H. Owaki et al.

    Elevated activity of myeloid growth factor in bone marrow adjacent to joints affected by rheumatoid arthritis

    J Rheumatol

    (1989)
  • S. Kotake et al.

    Detection of myeloid precursors (granulocyte/macrophage colony forming units) in the bone marrow adjacent to rheumatoid arthritis joints

    J Rheumatol

    (1992)
  • Jd Geratz et al.

    Suppression of streptococcal cell wall-induced arthritis by a potent protease inhibitor, bis (5-amidino-2-benzimidazolyl) methane

    Arthritis Rheum

    (1988)
  • K. Hayashida et al.

    Bone marrow changes in adjuvant-induced and collagen-induced arthritis

    Arthritis Rheum

    (1992)
  • Me Brandes et al.

    Transforming growth factor β1 suppresses acute and chronic arthritis in experimental animals

    J Clin Invest

    (1991)
  • Gs Buchan et al.

    The response of human peripheral blood mononuclear phagocytes to rheumatoid arthritis

    J Leukocyte Biol

    (1985)
  • Wd Xu et al.

    Cytokines in chronic inflammatory arthritis. II granulocyte-macrophage colony-stimulating factor in rheumatoid synovial effusions

    J Clin Invest

    (1989)
  • Gs Firestein et al.

    Cytokines in chronic inflammatory arthritis: 1 failure to detect T cell lymphokines (IL-2 and IL-3) and presence of macrophage colony stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis

    J Exp Med

    (1988)
  • Jm Alvaro-Gracia et al.

    Cytokines in chronic inflammatory arthritis. VI analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-&agr

    J Immunol

    (1991)
  • Ik Campbell et al.

    Human articular cartilage and chondrocytes produce hemopoietic colony-stimulating factors in culture in response to IL-1

    J Immunol

    (1991)
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